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BioMed Research International
Volume 2014, Article ID 416727, 10 pages
http://dx.doi.org/10.1155/2014/416727
Research Article

Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs

1Department of Anatomy and Physiology, 228 Coles Hall, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
2Intrexon Corporation, 108 TW Alexander Drive, Durham, NC 27709, USA
3Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
4The Scripps Research Institute, 130 Scripps Way No. 3B3, Jupiter, FL 33487, USA

Received 18 November 2013; Revised 5 January 2014; Accepted 8 January 2014; Published 26 February 2014

Academic Editor: Denis Archambault

Copyright © 2014 X. Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Holtkamp, J. B. Kliebenstein, E. J. Neumann et al., “Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers,” Journal of Swine Health and Production, vol. 21, no. 2, Article ID 72084, 2013. View at Google Scholar
  2. X. J. Meng, “Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development,” Veterinary Microbiology, vol. 74, no. 4, pp. 309–329, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. C. J. Nelsen, M. P. Murtaugh, and K. S. Faaberg, “Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents,” Journal of Virology, vol. 73, no. 1, pp. 270–280, 1999. View at Google Scholar · View at Scopus
  4. D. Nilubol, K. B. Platt, P. G. Halbur, M. Torremorell, and D. L. Harris, “The effect of a killed porcine reproductive and respiratory syndrome virus (PRRSV) vaccine treatment on virus shedding in previously PRRSV infected pigs,” Veterinary Microbiology, vol. 102, no. 1-2, pp. 11–18, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. P. Murtaugh and M. Genzow, “Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS),” Vaccine, vol. 29, no. 46, pp. 8192–8204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Martelli, S. Gozio, L. Ferrari et al., “Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: clinical protection and cell-mediated immunity,” Vaccine, vol. 27, no. 28, pp. 3788–3799, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. F. Geldhof, M. Vanhee, W. Van Breedam, J. Van Doorsselaere, U. U. Karniychuk, and H. J. Nauwynck, “Comparison of the efficacy of autogenous inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccines with that of commercial vaccines against homologous and heterologous challenges,” BMC Veterinary Research, vol. 182, no. 3, pp. 1–16, 2012. View at Google Scholar
  8. I. Díaz, L. Darwich, G. Pappaterra, J. Pujols, and E. Mateu, “Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus,” Journal of General Virology, vol. 86, no. 7, pp. 1943–1951, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Thanawongnuwech and S. Suradhat, “Taming PRRSV: revisiting the control strategies and vaccine design,” Virus Research, vol. 154, no. 1-2, pp. 133–140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Weesendorp, S. Morgan, N. Stockhofe-Zurwieden, D. J. Popma-De Graaf, S. P. Graham, and J. M. Rebel, “Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence,” Veterinary Microbiology, vol. 163, no. 1-2, pp. 1–12, 2013. View at Google Scholar
  11. Z. U. Islam, S. C. Bishop, N. J. Savill et al., “Quantitative analysis of porcine reproductive and respiratory syndrome (PRRS) viremia profiles from experimental infection: a statistical modelling approach,” PLoS ONE, vol. 12, no. 8, Article ID e83567, 2013. View at Google Scholar
  12. X. Li, A. Galliher-Beckley, H. Huang, X. Sun, and J. Shi, “Peptide nanofiber hydrogel adjuvanted live virus vaccine enhances cross-protective immunity to porcine reproductive and respiratory syndrome virus,” Vaccine, vol. 31, no. 41, pp. 4508–4515, 2013. View at Publisher · View at Google Scholar
  13. P. G. Halbur, P. S. Paul, M. L. Frey et al., “Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus,” Veterinary Pathology, vol. 32, no. 6, pp. 648–660, 1995. View at Google Scholar · View at Scopus
  14. X. Li, A. Galliher-Beckley, J. C. Nietfeld, K. S. Faaberg, and J. Shi, “Montanide Gel01 ST adjuvant enhances PRRS modified live vaccine efficacy by regulating porcine humoral and cellular immune responses,” World Journal of Vaccines, vol. 3, no. 1, pp. 1–9, 2013. View at Publisher · View at Google Scholar
  15. O. J. Lopez and F. A. Osorio, “Role of neutralizing antibodies in PRRSV protective immunity,” Veterinary Immunology and Immunopathology, vol. 102, no. 3, pp. 155–163, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Vanhee, P. L. Delputte, I. Delrue, M. F. Geldhof, and H. J. Nauwynck, “Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies,” Veterinary Research, vol. 40, no. 6, p. 63, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Lawson, J. Lunney, F. Zuckermann et al., “Development of an 8-plex Luminex assay to detect swine cytokines for vaccine development: assessment of immunity after porcine reproductive and respiratory syndrome virus (PRRSV) vaccination,” Vaccine, vol. 28, no. 32, pp. 5356–5364, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Guo, K. M. Lager, J. N. Henningson et al., “Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus,” Virology, vol. 435, no. 2, pp. 372–384, 2013. View at Google Scholar
  19. X. Leng, Z. Li, M. Xia, Y. He, and H. Wu, “Evaluation of the efficacy of an attenuated live vaccine against highly pathogenic porcine reproductive and respiratory syndrome virus in young pigs,” Clinical Vaccine Immunology, vol. 19, no. 8, pp. 1199–1206, 2012. View at Publisher · View at Google Scholar
  20. Z. J. Tian, T. Q. An, Y. J. Zhou et al., “An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS,” Veterinary Microbiology, vol. 138, no. 1-2, pp. 34–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. F. A. Osorio, J. A. Galeota, E. Nelson et al., “Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity,” Virology, vol. 302, no. 1, pp. 9–20, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. C. J. Wei, J. C. Boyington, P. M. McTamney et al., “Induction of broadly neutralizing H1N1 influenza antibodies by vaccination,” Science, vol. 329, no. 5995, pp. 1060–1064, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Wang, Y. Nan, Y. Yu, Z. Yang, and Y. J. Zhang, “Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus,” Veterinary Microbiology, vol. 166, no. 3-4, pp. 493–503, 2013. View at Publisher · View at Google Scholar
  24. J. K. Lunney, E. R. Fritz, J. M. Reecy et al., “Interleukin-8, interleukin-1β, and interferon-γ levels are linked to PRRS virus clearance,” Viral Immunology, vol. 23, no. 2, pp. 127–134, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. V. Dwivedi, C. Manickam, B. Binjawadagi, D. Linhares, M. P. Murtaugh, and G. J. Renukaradhya, “Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions,” Virology Journal, vol. 9, no. 45, pp. 1–9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Suradhat and R. Thanawongnuwech, “Upregulation of interleukin-10 gene expression in the leukocytes of pigs infected with porcine reproductive and respiratory syndrome virus,” Journal of General Virology, vol. 84, no. 10, pp. 2755–2760, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Xiao, L. Batista, S. Dee, P. Halbur, and M. P. Murtaugh, “The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load,” Journal of Virology, vol. 78, no. 11, pp. 5923–5933, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Gómez-Laguna, F. J. Salguero, M. F. De Marco, F. J. Pallarés, A. Bernabé, and L. Carrasco, “Changes in lymphocyte subsets and cytokines during European porcine reproductive and respiratory syndrome: increased expression of IL-12 and IL-10 and proliferation of CD4-CD8high,” Viral Immunology, vol. 22, no. 4, pp. 261–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Piriou-Guzylack and H. Salmon, “Membrane markers of the immune cells in swine: an update,” Veterinary Research, vol. 39, no. 6, pp. 54–82, 2008. View at Publisher · View at Google Scholar · View at Scopus