BioMed Research International / 2014 / Article / Tab 2

Research Article

Survey on Knowledge, Attitudes, and Training Needs of Italian Residents on Genetic Tests for Hereditary Breast and Colorectal Cancer

Table 2

Knowledge of residents () on genetic tests for breast and colorectal cancer, prevalence of hereditary forms, and penetrance of BRCA1/2 and APC mutations.

Number of responders to the question% of correct answersCI 95%

BRCA1/2
 Genetic tests for BRCA1/BRCA2 mutations are able to identify patients at high risk to develop  breast cancer (agree, uncertain, disagree)35793.390.2–95.6
 The percentage of breast cancer cases associated with mutations in BRCA1/BRCA2 is 110%,  15–35%, >35%35442.937.7–48.3
 The absolute risk of developing breast cancer in presence of BRCA1/BRCA2 mutations is  <10%, 4080%, 100%35680.375.8–84.3
 Women with breast cancer and strong family history should perform BRCA1/BRCA2 testing  (agree, uncertain, disagree)35678.774.0–82.8
 Scientific evidence recommend for BRCA1/BRCA2 positive women clinical and instrumental  surveillance starting from the age of 25 (agree, uncertain, disagree)35884.480.2–88.0
APC
 Genetic tests for APC mutations are able to identify patients who will develop colorectal  carcinoma (agree, uncertain, disagree)35577.773.1–82.0
 The percentage of colon cancer cases associated with APC mutations is <5%, 10–25%, >40%35231.827.0–37.0
 The absolute risk of developing colorectal cancer in presence of APC mutations is <10%,  40–80%, 100%35127.923.3–32.9
 APC testing is recommended for 10–12 years old children with a first degree relative with  known APC mutation (agree, uncertain, disagree)35757.452.1–62.6
 Scientific evidence recommend for APC positive individuals periodic colonoscopy starting  from the age of 10–15 (agree, uncertain, disagree)35655.950.6–61.1

Correct answers are in bold.