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BioMed Research International
Volume 2014, Article ID 419376, 8 pages
http://dx.doi.org/10.1155/2014/419376
Research Article

Through Diffusion Tensor Magnetic Resonance Imaging to Evaluate the Original Properties of Neural Pathways of Patients with Partial Seizures and Secondary Generalization by Individual Anatomic Reference Atlas

1Department of Electrical Engineering, National Central University, Jhongli, Taoyuan 32001, Taiwan
2Epilepsy Center, Buddhist Tzu Chi General Hospital, Hualian, Hualian 97002, Taiwan
3Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan
4Department of Neurology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung 40201, Taiwan

Received 25 December 2013; Revised 4 April 2014; Accepted 6 April 2014; Published 5 May 2014

Academic Editor: Carl Muroi

Copyright © 2014 Syu-Jyun Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with high-resolution and diffusion tensor MRIs. Automated demarcation of supratentorial fibers was accomplished with personalized fiber-labeled atlases. From the individual atlases, we observed significant elevation of mean diffusivity (MD) in fornix (cres)/stria terminalis (FX/ST) and sagittal stratum (SS) and a significant difference in fractional anisotropy (FA) among FX/ST, SS, posterior limb of the internal capsule (PLIC), and posterior thalamic radiation (PTR). For patients with early-onset epilepsy, the diffusivities of the SS and the retrolenticular part of the internal capsule were significantly elevated, and the anisotropies of the FX/ST and SS were significantly decreased. In the drug-resistant subgroup, the MDs of SS and PTR and the FAs of SS and PLIC were significantly different. Onset age was positively correlated with increases in FAs of the genu of the corpus callosum. Patients with neocortical seizures and secondary generalisation had microstructural anomalies in WM. The changes in WM are relevant to early onset, progression, and severity of epilepsy.