Diagnostic and Prognostic Value of Soluble Syndecan-1 in Pleural Malignancies

Figure 3

Soluble syndecan-1 has a diagnostic value for malignancy in pleural effusions. ROC plots for syndecan-1 in pleural effusions and serum (a) and osteopontin in pleural effusions and serum (b). Figures (c) to (f) only pertain to pleural effusions. Calibration curves evaluate the relation between the predicted and actual probabilities for soluble syndecan-1 and osteopontin, panels (c) and (d), respectively. Nagelkerke’s 𝑟² is displayed in Figures (c) and (d). Box plots of predicted risks show a greater discrimination between malignant and benign effusions when using syndecan-1 as opposed to osteopontin (e, f). Discrimination slopes (DS; dotted lines) are calculated as the difference between mean predicted risks (+). Boxes show median and interquartile ranges, while whiskers represent the 5th to 95th percentile. Outliers are presented as black dots.