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BioMed Research International
Volume 2014, Article ID 420830, 7 pages
Research Article

Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

1Department of Periodontology, School of Dentistry, Ege University, 35100 Izmir, Turkey
2Department of Pediatric Immunology, School of Medicine, Ege University, 35100 Izmir, Turkey

Received 13 February 2014; Accepted 15 April 2014; Published 19 May 2014

Academic Editor: Georgios E. Romanos

Copyright © 2014 Oya Türkoğlu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA. Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting age . No differences were found in GCF cathepsin C levels among the study groups . Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amounts but not with cathepsin C total amounts . Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.