Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials

Table 2

Results for mortality.

Outcome	Number of; included trials	AVP/terlipressin; animals	Control; animals	OR	95% CI	for effect	for heterogeneity	(%)
Overall trials	15	174	259	0.09	0.05–0.15	<0.001	0.30	14
Mortality		15%	63%
Placebo as comparator drug	7	72	48	0.03	0.01–0.09	<0.001	0.57	0
Mortality		18%	92%
Fluid resuscitation as comparator drug	11	114	117	0.08	0.04–0.15	<0.001	0.75	0
Mortality		18%	67%
Vasopressors (NE or epinephrine) as comparator drug	7	88	87	0.18	0.08–0.44	<0.001	0.96	0
Mortality		18%	39%
NE as comparator drug	4	54	53	0.16	0.06–0.45	<0.001	0.97	0
Mortality		20%	47%
Sensitivity analysis (including only low risk of bias studies)	10	134	195	0.13	0.08–0.24	<0.001	0.99	0
Mortality		18%	57%