Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection
Figure 7
Cytokine mRNA expression levels in lung. Groups of animals were immunized intranasally three times with PBS, CTB, rFim2, or CTB-Fim2 every 12 days followed by intranasal challenge with UFC of the Tohama I strain of B. pertussis. At 8 days postinfection, animals were killed and lung samples were collected for measuring mRNA levels of IFN-γ (a) and IL-4 (b). Statistical differences were observed between CTB-Fim2 and all other groups except rFim2 .
