Research Article

Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Table 3

Optimization of encapsulation of liposomal Res.

Drug : lipid ratio (w/w) Encapsulation efficiency (%)

1 : 10
1 : 20
1 : 40
1 : 60
1 : 40 : 8*
1 : 20 : 1*
1 : 40 : 1*
1 : 40 : 2*
1 : (38 : 2)**
1 : (18 : 2)**
1 : 1 : (18 : 2)***

denotes that these groups are significantly different from 1 : 40 ratio ( ).
bdenotes that the group is significantly different from the 1 : 40 : 2 ratio ( ).
cdenotes that the group is significantly different from the 1 : 38 : 2 ratio ( ).
*denotes Res : EPC : 5-FU (dual encapsulated formulation without DSPE-PEG).
**denotes Res : EPC : DSPE-PEG (PEGylated Res formulation).
***denotes 5-FU :  Res : EPC : DSPE-PEG (PEGylated dual liposomal formulation).