Research Article

Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Table 5

Combination index (CI) of different resveratrol and 5-FU combinations in  vitro and grading as per the literature Chou, 2006 [34] .

Resveratrol (μm) 5-FU (μm) CI grade

3 0.5 ± (nearly additive)
1.5 − − − (antagonism)
2.5 − − − − (strong antagonism)
5 − (slight antagonism)

5 0.5 − − − (antagonism)
1.5 − − − − (strong antagonism)
2.5 − − − − (strong antagonism)
5 − − (moderate antagonism)

10 0.5 − − − (antagonism)
1.5 − − − − (strong antagonism)
2.5 − − − − − (very strong antagonism)
5 − − − (antagonism)

15 0.25 + + + (synergism)
0.5 + + (moderate synergism)
1 + (slight synergism)
2 − − (moderate antagonism)
4 − − − (antagonism)

30 0.25 + + (moderate synergism)
0.5 + + (moderate synergism)
1 − (slight antagonism)
1.5 + + + + (strong synergism)
2 − − − (antagonism)
2.5 + + + (synergism)
5 + + + (synergism)