Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy
Table 2
The clinical characteristics and urokinase gene 3′-UTR gene polymorphism and its activity.
C/C (n = 82)
C/T (n = 9)
P value
Male gender (%)
42 (51.8%)
7 (77.8%)
0.121
Age of onset (yrs)
52.5 ± 15.7
51.4 ± 25.2
0.847
Age of biopsy (yrs)
58.2 ± 15.4
53.9 ± 25.0
0.463
Follow-up period (yrs)
9.6 ± 6.0
7.8 ± 5.8
0.390
BMI (Kg/M2)
24.7 ± 3.6
24.0 ± 3.3
0.557
MBP (mmHg)
98.6 ± 12.2
101.5 ± 24.2
0.553
Albumin (mg/dL)
2.5 ± 0.6
2.7 ± 0.5
0.338
Cholesterol (mg/dL)
347.7 ± 137.3
298.9 ± 113.3
0.307
Triglyceride (mg/dL)
236.3 ± 165.0
161.2 ± 119.5
0.189
Crinitial (mg/dL)
1.3 ± 1.1
1.4 ± 1.1
0.788
DUPinitial (g/day)
7.0 ± 8.2
7.1 ± 4.7
0.974
CCrinitial (mL/min)
87.6 ± 41.2
81.0 ± 45.6
0.655
PT (second)
11.2 ± 0.8
11.6 ± 0.8
0.290
aPTT (second)
27.0 ± 5.2
30.0 ± 3.2
0.144
Crfinal (mg/dL)
3.3 ± 4.3
1.2 ± 0.4
0.150
DUPfinal (g/day)
2.6 ± 3.5
1.1 ± 1.3
0.197
CCrfinal (mL/min)
52.1 ± 39.2
76.4 ± 26.7
0.075
Proteinuria ≧ 3.5 g/day
28 (34.1%)
3 (33.3%)
0.838
Hematuria
46 (56.1%)
4 (44.4%)
0.374
Lower leg edema
69 (84.1%)
7 (77.8%)
0.451
Urine uPA (ng/mL)
6.17 ± 4.68
6.06 ± 5.37
0.962
BMI: body mass index; MBP: mean blood pressure; DUP: daily urinary protein excretion; CCr: creatinine clearance. All data are presented as mean ± SD; urine uPA: urine urokinase plasminogen activator. There were only 28 urine samples collected from patients with C/C (n = 22) and C/T genotypes (n = 6) of urokinase gene 3′-UTR gene polymorphism for the functional study of urine uPA.
