Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression
Effect of 2ME2 on renal morphology in renal I/R injury. Renal injury was evidenced by massive TEC necrosis or the damage or loss of brush border (arrows) and by tubular dilation and cast formation (arrowheads). (a) Sham control; (b) I/R-only; (c) I/R + 2ME2: I/R mice injected with 2ME2 (10 mg/kg, i.p.); and (d) I/R+2ME2: I/R mice injected with 2ME2 (20 mg/kg, i.p.). H&E staining was used to evaluate the degree of acute renal tubules damage in renal I/R injury. Representative data are shown. Sections were observed under a microscope (×400). Scale bar is 50 μm. The histological scores of tubular injury in the cortex (e), corticomedullary junction (CMJ) (f), and medulla (g) of all groups of mice are shown. Values are mean ± SD. All groups: . compared with control mice and compared with I/R-only mice.