Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 431524, 11 pages
http://dx.doi.org/10.1155/2014/431524
Research Article

Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

1Department of Medical Research, Chi-Mei Medical Center, Tainan 710, Taiwan
2Department of Biotechnology, National Formosa University, Yunlin County 632, Taiwan
3Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua 515, Taiwan
4Department of Anesthesia & Medical Research, China Medical University, An Nan Hospital, Tainan 710, Taiwan
5Department of Surgery, Chi-Mei Medical Center, Tainan 710, Taiwan
6Department of Anaesthesiology, Chi-Mei Medical Center, Tainan 710, Taiwan
7Department of Anesthesiology, Taipei Medical University, Taipei 110, Taiwan

Received 25 April 2014; Revised 5 June 2014; Accepted 1 July 2014; Published 6 August 2014

Academic Editor: Raul Lombardi

Copyright © 2014 Ying-Yin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Sadis, G. Teske, G. Stokman et al., “Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway,” PLoS ONE, vol. 2, no. 5, article e469, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Munshi, C. Hsu, and J. Himmelfarb, “Advances in understanding ischemic acute kidney injury,” BMC Medicine, vol. 9, article 11, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. T. Burns, D. R. Davies, A. J. Mclaren, L. Cerundolo, P. J. Morris, and S. V. Fuggle, “Apoptosis in ischemia/reperfusion injury of human renal allografts,” Transplantation, vol. 66, no. 7, pp. 872–876, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Hayashi, Y. Saitou, K. Nose, T. Nishioka, T. Ishii, and H. Uemura, “Efficacy of carvedilol for ischemia/reperfusion-induced oxidative renal injury in rats,” Transplantation Proceedings, vol. 40, no. 7, pp. 2139–2141, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Kher, K. K. Meldrum, K. L. Hile et al., “Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia-reperfusion,” Journal of Thoracic and Cardiovascular Surgery, vol. 130, no. 3, pp. 662.e1–669.e1, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Kim, Y. M. Seok, K. Jung, and K. M. Park, “Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice,” The American Journal of Physiology: Renal Physiology, vol. 297, no. 2, pp. F461–F470, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. E. Sabbahy and V. S. Vaidya, “Ischemic kidney injury and mechanisms of tissue repair,” Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 3, no. 5, pp. 606–618, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. K. J. Johnson and J. M. Weinberg, “Postischemic renal injury due to oxygen radicals,” Current Opinion in Nephrology and Hypertension, vol. 2, no. 4, pp. 625–635, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Dobashi, B. Ghosh, J. K. Orak, I. Singh, and A. K. Singh, “Kidney ischemia-reperfusion: modulation of antioxidant defenses,” Molecular and Cellular Biochemistry, vol. 205, no. 1-2, pp. 1–11, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Ricker, Z. Chen, X. P. Yang, V. S. Pribluda, G. M. Swartz, and C. van Waes, “2-Methoxyestradiol inhibits hypoxia-inducible factor 1α, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma,” Clinical Cancer Research, vol. 10, no. 24, pp. 8665–8673, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. V. S. Pribluda, E. R. J. Gubish, T. M. LaVallee, A. Treston, G. M. Swartz, and S. J. Green, “2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate,” Cancer and Metastasis Reviews, vol. 19, no. 1-2, pp. 173–179, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. Tevaarwerk, K. D. Holen, D. B. Alberti et al., “Phase i trial of 2-methoxyestradioI NanoCrystal dispersion in advanced solid malignancies,” Clinical Cancer Research, vol. 15, no. 4, pp. 1460–1465, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. S. Chua, Y. L. Chua, and T. Hagen, “Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity,” Molecular Cancer Therapeutics, vol. 9, no. 1, pp. 224–235, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. N. J. Mabjeesh, D. Escuin, T. M. LaVallee et al., “2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF,” Cancer Cell, vol. 3, no. 4, pp. 363–375, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Li, Z. Xia, and L. Chen, “HIF-1-alpha and survivin involved in the antiapoptotic effect of 2ME2 after global ischemia in rats,” Neurological Research, vol. 33, no. 6, pp. 583–592, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Yeh, L. Ou, P. Gean, J. Hung, and W. Chang, “Selective inhibition of early-but not late-expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage,” Brain Pathology, vol. 21, no. 3, pp. 249–262, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Chen, Q. Hu, J. Yan et al., “Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model,” Journal of Neurochemistry, vol. 102, no. 6, pp. 1831–1841, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. C.-H. Yeh, W. Chou, C.-C. Chu et al., “Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide,” Shock, vol. 36, no. 5, pp. 510–516, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Helton, J. Cui, J. R. Scheel et al., “Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage,” Journal of Neuroscience, vol. 25, no. 16, pp. 4099–4107, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Rosenberger, S. Mandriota, J. S. Jürgensen et al., “Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys,” Journal of the American Society of Nephrology, vol. 13, no. 7, pp. 1721–1732, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Lee, S. Bae, J. Jeong, S. Kim, and K. Kim, “Hypoxia-inducible factor (HIF-1)α: Its protein stability and biological functions,” Experimental and Molecular Medicine, vol. 36, no. 1, pp. 1–12, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Matsumoto, Y. Makino, T. Tanaka et al., “Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats,” Journal of the American Society of Nephrology, vol. 14, no. 7, pp. 1825–1832, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. W. M. Bernhardt, C. Warnecke, C. Willam, T. Tanaka, M. S. Wiesener, and K. Eckardt, “Organ protection by hypoxia and hypoxia-inducible factors,” Methods in Enzymology, vol. 435, pp. 219–245, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. W. Calvert, J. Cahill, M. Yamaguchi-Okada, and J. H. Zhang, “Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1α and its downstream target genes,” Journal of Applied Physiology, vol. 101, no. 3, pp. 853–865, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. C.-H. Yeh, W. Cho, E. C. So et al., “Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1α expression,” British Journal of Anaesthesia, vol. 106, no. 4, pp. 590–599, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Li, C. Zhou, J. W. Calvert, A. R. T. Colohan, and J. H. Zhang, “Multiple effects of hyperbaric oxygen on the expression of HIF-1α and apoptotic genes in a global ischemia-hypotension rat model,” Experimental Neurology, vol. 191, no. 1, pp. 198–210, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Chen, V. Jadhav, J. Tang, and J. H. Zhang, “HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model,” Neurobiology of Disease, vol. 31, no. 3, pp. 433–441, 2008. View at Publisher · View at Google Scholar · View at Scopus