Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
Table 2
Association between alleles of SNPs at 6p21.3 and NPC in phase I and phase II combined.
Gene-SNP
Risk allele
Phase I and phase II
Phase I and phase II
Phase II
OR (95% CI)*
OR (95% CI)**
OR (95% CI)***
GABBR1-rs2267633
A
1.61 (1.41–1.84)
1.48 (1.17–1.87)
0.001
1.41 (1.02–1.95)
0.03
GABBR1-rs29230
T
1.64 (1.45–1.89)
1.61 (1.28–2.04)
1.61 (1.16–2.22)
0.004
GABBR1-rs29232
A
1.35 (1.21–1.49)
1.41 (1.16–1.71)
0.0006
1.33 (1.01–1.76)
0.05
HLA-F-rs3129055
G
1.14 (1.02–1.28)
0.02
1.33 (1.09–1.64)
0.008
1.47 (1.10–1.20)
0.01
HLA-A-rs2517713
T
1.61 (1.43–1.82)
1.69 (1.35–2.08)
1.64 (1.20–2.22)
0.003
HCG9-rs9260734
G
1.67 (1.47–1.87)
1.75 (1.41–2.17)
1.75 (1.28–2.44)
0.0005
HCG9-rs3869062
A
1.60 (1.42–1.81)
1.63 (1.30–2.04)
1.60 (1.16–2.19)
0.004
HCG9-rs5009448
C
1.62 (1.45–1.82)
1.66 (1.33–2.06)
1.64 (1.20–2.26)
0.002
HCG9-rs16896923
T
1.54 (1.35–1.75)
1.69 (1.33–2.13)
1.64 (1.18–2.27)
0.005
OR: odds ratio. CI: confidence interval.
*Adjusted for sex and age.
**Additionally adjusted for EBV/IgA/VCA and EBV/IgA/EA titers.
***Additionally adjusted for EBV/IgA/VCA and EBV/IgA/EA antibody titers and other environmental factors including family history with NPC, consumption of salt-preserved fish, exposure to domestic wood cooking fires, and exposure to occupational solvents.
