Network Based Integrated Analysis of Phenotype-Genotype Data for Prioritization of Candidate Symptom Genes

Figure 1

The integration of phenotype-genotype data. Symptom-disease associations are extracted based on the fact that the symptom and disease appeared in same bibliographic record (including title, abstract, and MeSH) of PubMed. Three disease gene association databases (i.e., OMIM, CTD, and PharmGKB) and five human PPI databases (i.e., HPRD, BioGrid, IntAct, MINT, and DIP) are integarted in this study. The relationships among symptoms (denoted s1–s4), diseases (denoted d1–d7), and proteins (denoted p1–p14) are then extracted.