Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats
Figure 2
Paraffin sections stained by haematoxylin and eosin (H&E, ×200) for histopathological examination of the kidney tissue of rats treated as follows: control group (a); lead acetate plus Omega-3, 125 mg/kg body weight group (b); lead acetate plus Omega-3, 260 mg/kg body weight group (c). Kidney tissue of lead acetate treated rats (d) showing disruption of Bowman’s capsule, shrunken glomeruli G with the capsular space S, and cytoplasmic pyknosis of some nuclei (), The degenerative changes in the epithelial cells lining the renal tubules (□), hemorrhagic area () in renal tubules, and dilation in the renal tubules are compared to normal histological structure of the glomerulus and tubules in control group (a). Histological alterations induced in lead acetate at both doses of Omega-3 groups (b) and (c) were markedly reduced.
), The degenerative changes in the epithelial cells lining the renal tubules (□), hemorrhagic area (
) in renal tubules, and dilation in the renal tubules are compared to normal histological structure of the glomerulus and tubules in control group (a). Histological alterations induced in lead acetate at both doses of Omega-3 groups (b) and (c) were markedly reduced.
