Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients

Table 6

Multiple linear regression between P2Y12 methylation levels and clinical factors.

Model		𝐵	𝑃coefficients	𝐹	𝑃𝐹value	𝑅 square
P2Y12 CpG1 with alcohol abuse	(Constant)	33.069	0.012	9.302	0.001	0.724
	TBIL	−0.362	0.013
	LEVF	0.690	0.001
	Albumin	−0.755	0.019
	AST	0.017	0.050
P2Y12 CpG2 with alcohol abuse	(Constant)	21.666	0.020	10.033	0.001	0.667
	LEVF	0.619	0.000^a
	Albumin	−0.668	0.010
	AST	0.017	0.014
P2Y12 CpG1 with current smoking	(Constant)	28.035	0.004	6.193	0.005	0.251
	LEVF	0.318	0.026
	TBIL	−0.314	0.049
P2Y12 CpG1 with Albumin <35	(Constant)	−19.001	0.109	14.345	0.000^a	0.840
	LEVF	0.643	0.000^a
	CRP	0.129	0.001
	BUN	2.228	0.006
	Triglycerides	3.205	0.044

aThe P value is less than 0.001.