¹⁸F-Labeled Silicon-Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals

Table 1

Hydrolytic half-lives (𝑡_1/2) of selected organofluorosilane building blocks.

Cpd	Structure	𝑡1/2 (h)	Reference
10		0.08^a	[33]
19		0.1^a	[33]
20		8^a	[33]
11		12^a	[33]
21		15^a	[33]
22		21^a	[33]
23		29^a	[33]
24		37^a	[33]
25		37^a	[33]
26		43^a	[33]
27		61^a	[33]
28		79^a	[33]
29		302^a	[33]
30		>300^a	[33]
16		>300^a	[33]
31		8^b	[36]
32		16^b	[36]
33		>>2^c	[32]

aHydrolytic stability determination from nonradioactive compounds in MeCN/aqueous buffer (2 : 1; pH 7) at room temperature. ^bHydrolytic stability determination from ¹⁸F-labeled compounds in EtOH/aqueous buffer at room temperature. ^c95% intact after 2 h of incubation; hydrolytic stability determination from ¹⁸F-labeled compounds at pH 7.4.