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BioMed Research International
Volume 2014 (2014), Article ID 459465, 11 pages
Review Article

Biomaterials in Cardiovascular Research: Applications and Clinical Implications

1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia
2Rubber Technology Centre, Indian Institute of Technology, Kharagpur, West Bengal 721302, India
3Department of Research and Development, PSNA College of Engineering and Technology, Kothandaraman Nagar, Dindigul, Tamil Nadu 624 622, India

Received 21 January 2014; Revised 29 March 2014; Accepted 31 March 2014; Published 8 May 2014

Academic Editor: Minetaro Ogawa

Copyright © 2014 Saravana Kumar Jaganathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular biomaterials (CB) dominate the category of biomaterials based on the demand and investments in this field. This review article classifies the CB into three major classes, namely, metals, polymers, and biological materials and collates the information about the CB. Blood compatibility is one of the major criteria which limit the use of biomaterials for cardiovascular application. Several key players are associated with blood compatibility and they are discussed in this paper. To enhance the compatibility of the CB, several surface modification strategies were in use currently. Some recent applications of surface modification technology on the materials for cardiovascular devices were also discussed for better understanding. Finally, the current trend of the CB, endothelization of the cardiac implants and utilization of induced human pluripotent stem cells (ihPSCs), is also presented in this review. The field of CB is growing constantly and many new investigators and researchers are developing interest in this domain. This review will serve as a one stop arrangement to quickly grasp the basic research in the field of CB.