Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance: An Impact on Female Fertility
Figure 8
Effect of IR and Cd either alone or in combination on StAR (a) mRNA expression, (b) densitometric analysis for mRNA, (c) protein expression, and (d) densitometric analysis for protein. The normalized expression values are represented as mean ± SEM of three independent experiments (). Cd demonstrated significant decrease in StAR mRNA expression ( and ##) when compared to control, IR, and IR + Cd group. StAR protein expression was significantly decreased (, , and ) in Cd, IR, and IR + Cd group when compared to control, (###) in Cd group when compared to IR group, and (@) in IR group when compared to IR + Cd group.
