Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance: An Impact on Female Fertility
Figure 9
Effect of IR and Cd either alone or in combination on CYP19A1 (a) mRNA expression, (b) densitometric analysis for mRNA, (c) protein expression, and (d) densitometric analysis for protein. The normalized gene expression values are represented as mean ± SEM of three independent experiments . Cd and IR groups showed significant decrease () in CYP19A1 mRNA expression as compared to control. Cd and IR showed significant decrease (## and @@@), respectively, in CYP19A1 mRNA expression when compared to IR + Cd. CYP19A1 protein was significantly decreased in Cd and IR group () as compared to control.
