Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets
Figure 1
Network of signaling cascade involved in tumor progression and radioresistance. The scheme shows tyrosine kinase axis and its signaling cascade leading to cell proliferation, migration, angiogenesis, apoptosis, and DNA damage, some of them activated by phosphorylation (p). These signaling pathways are involved in radiation resistance and are promising targets to improve radiotherapy (IP3R = receptor of inositol 1,4,5-trisphosphate and NR = nucleoplasmic reticulum).
