Research Article

Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal Activity

Table 3

Weights of the organs relative to the body weights (%) of the female and male Wistar rats that were subchronically exposed to LQM 919 or LQM 996.

Liver, kidney, brain, and spleen weights relative to body weight (%)
TreatmentLiverKidneyBrainSpleen
FemalesMalesFemalesMalesFemalesMalesFemalesMales

LQM 919 (50 mg/kg/day)3.43 (±0.18)a3.22 (±0.22)a0.36 (±0.02)a0.35 (±0.04)a0.75 (±0.07)a0.49 (±0.04)a0.38(±0.08)b0.28(±0.04)b
LQM 919 (25 mg/kg/day)3.86 (±0.47)a3.08 (±0.03)a0.33 (±0.01)a0.33 (±0.01)a0.70 (±0.17)a0.41 (±0.14)a0.51(±0.17)b0.41(±0.14)b
LQM 919 (12.5 mg/kg/day)3.35 (±0.33)a3.54 (±0.37)a0.35 (±0.04)a0.33 (±0.01)a0.65 (±0.04)a0.52 (±0.10)a0.35(±0.04)a0.22(±0.01)a
LQM 919 (25 mg/kg/day) Sg3.83 (±0.01)a3.60 (±0.24)a0.34 (±0.04)a0.34 (±0.02)a0.67 (±0.05)a0.38 (±0.01)a0.26 (±0.00)a0.18 (±0.03)a

LQM 996 (50 mg/kg/day)3.96 (±0.34)a3.55 (±0.24)a0.33 (±0.02)a0.33 (±0.01)a0.71 (±0.08)a0.47 (±0.04)a0.47 (±0.06)b0.44 (±0.08)b
LQM 996 (25 mg/kg/day)3.90 (±0.53)a3.60 (±0.03)a0.35 (±0.02)a0.35 (±0.05)a0.72 (±0.09)a0.48 (±0.05)a0.55 (±0.07)b0.39 (±0.08)b
LQM 996 (12.5 mg/kg/day)3.69 (±0.39)a3.46 (±0.30)a0.33 (±0.03)a0.33 (±0.03)a0.69 (±0.10)a0.50 (±0.08)a0.37 (±0.04)a0.31 (±0.06)b
LQM 996 (25 mg/kg/day) Sg3.53 (±0.40)a3.51 (±0.06)a0.34 (±0.00)a0.33 (±0.03)a0.72 (±0.15)a0.38 (±0.03)a0.25 (±0.01)a0.24 (±0.04)a

Control group3.59 (±0.21)a3.25 (±0.17)a0.33 (±0.01)a0.32 (±0.02)a0.69 (±0.08)a0.46 (±0.03)a0.26 (±0.02)a0.19 (±0.03)a

Sg: satellite group. Different letters indicate statistical differences between means ( ).