Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal Activity
Table 4
Effects of subchronic exposure to LQM 919 on selected parameters in male and female Wistar rats.
Parameter
Group
Females
Males
Control (—)
12.5 mg/kg/day
25 mg/kg/day
25 mg/kg/day (Sg)
50 mg/kg/day
Control (—)
12.5 mg/kg/day
25 mg/kg/day
25 mg/kg/day (Sg)
50 mg/kg/day
AST (U/L)
238.2 (±78.13)
259.0 (±130.4)
152.0 (±17.12)
125.6 (±2.81)
202.3 (±72.55)
195.8 (±70.16)
166.5 (±28.12)
276.7 (±110.3)
358.2 (±49.30)*
237.1 (±62.47)
ALT (U/L)
61.52 (±19.55)
51.34 (±12.73)
68.68 (±29.46)
76.13 (±5.54)
59.20 (±9.31)
60.64 (±32.21)
76.05 (±1.96)
63.27 (±12.37)
45.97 (±10.45)
73.18 (±8.11)
LDH (U/L)
924.2 (±285.6)
851.3 (±192.9)
410.5 (±95.73)
370.7 (±62.00)
664.6 (±435.2)
739.5 (±334.1)
558.0 (±225.9)
553.7 (±246.8)
660.7 (±263.0)
872.0 (±464.4)
GGT (U/L)
1.71 (±2.28)
1.08 (±1.14)
0.77 (±0.90)
0.38 (±0.02)
0.18 (±0.26)
0.34 (±0.25)
0.51 (±0.42)
0.43 (±0.75)
0.25 (±0.42)
1.33 (±0.99)
CHE (U/L)
953.9 (±526.7)
1404 (±794.8)
982.2 (±116.6)
1132 (±444.2)
1088 (±137.8)
344.3 (±111.1)
459.0 (±138.5)
466.2 (±96.50)
344.6 (±33.32)
237.28 (±140.31)
Creatinin (mg/dL)
0.44 (±0.20)
0.64 (±0.07)
0.68 (±0.09)
0.53 (±0.16)
0.75 (±0.16)*
0.54 (±0.12)
0.65 (±0.14)
0.65 (±0.15)
0.46 (±0.04)
0.74 (±0.01)*
Total protein (g/dL)
5.83 (±1.07)
6.85 (±0.67)
7.26 (±0.43)
7.42 (±0.18)
6.61 (±0.98)
5.52 (±0.76)
6.52 (±0.29)
6.27 (±1.48)
5.80 (±0.27)
7.08 (±0.28)*
Albumin (g/dL)
2.36 (±1.05)
1.98 (±0.87)
3.71 (±0.32)
2.32 (±1.44)
3.09 (±0.77)
1.72 (±0.86)
2.72 (±0.95)
1.87 (±0.10)
2.36 (±0.28)
1.99 (±0.91)
Globulin (g/dL)
3.47 (±0.89)
4.87 (±1.45)
3.55 (±0.13)
5.09 (±1.51)
3.52 (±1.35)
3.80 (±0.27)
3.81 (±1.67)
4.40 (±1.56)
3.45 (±0.55)
5.09 (±0.82)
Reticulocytes (%)
4.21 (±0.35)
6.13 (±0.74)
5.78 (±0.72)
3.87 (±0.79)
6.66 (±1.49)*
3.93 (±0.77)
5.44 (±1.07)*
6.15 (±0.53)*
2.75 (±0.95)
5.87 (±0.66)*
Hematocrit (%)
36.6 (±2.92)
41.70 (±2.16)
33.20 (±8.78)
29.33 (±9.45)
39.80 (±6.41)
35.70 (±3.89)
43.00 (±2.82)
28.33 (±6.65)
37.33 (±3.05)
48.00 (±5.56)*
A/G
0.74 (±0.39)
0.49 (±0.45)
1.04 (±0.06)
0.54 (±0.44)
1.00 (±0.39)
0.46 (±0.24)
0.76 (±0.34)
0.48 (±0.24)
0.70 (±0.19)
0.43 (±0.29)
AST: aspartate aminotransferase, ALT: alanine aminotransferase, LDH: lactate dehydrogenase, GGT: gamma-glutamyltransferase, CHE: cholinesterase, A/G: albumin and globulin, Sg: satellite group. Values are presented as the means ± the SDs. (significantly different from the unexposed group).
