Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis

Table 3

Serum biochemical analysis data of male and female rats administered the green mussel formulation after subchronic (90 days) toxicity studies.

		SGOT	SGPT	ALP	Bilirubin	Total protein	Albumin	Globulin	A/G ratio	Urea	Creatinine
		(U/L)	(U/L)	(U/L)	(mg/dL)	(g/dL)	(g/dL)	(g/dL)		(mg/dL)	(mg/dL)
Male	Control^a	182.00±3.14	68.40±1.5	356.20±2.84	0.20±0.01	7.82±0.22	3.50±0.07	4.32±0.42	0.81	46.80±0.96	0.68±0.08
	2.0 g/kg^b	188.60±1.5	73.80±10.53	254.40±3.18^∗	0.20±0.07	7.44±0.16	3.54±0.03	3.90±0.02	0.91	50.80±0.15	0.62±0.04
	1.0 g/kg^b	171.00±14.93	78.40±0.02	332.80±2.49	0.18±0.04	7.06±0.06	3.54±0.26	3.52±0.34	1.02	42.00±0.54	0.62±0.08
	0.50 g/kg^b	146.00±20.73^∗	68.80±0.42	254.40±2.44^∗	0.18±0.04	7.44±0.26	3.54±0.41	3.90±0.51	0.93	32.00±0.87^∗	0.62±0.13
Female	Control^a	195.40±10.01	86.40±1.57	267.40±23	0.22±0.04	7.52±0.26	4.14±0.21	3.38±0.08	1.23	77.00±5.94	0.78±0.03
	2.0 g/kg^b	132.60±3.04^∗	63.40±1.99	340.20±4.94	0.16±0.05	7.22±0.21	3.94±0.27	3.28±0.3	1.20	49.00±2.16^∗	0.56±0.09
	1.0 g/kg^b	161.25±30.13	64.00±0.81	344.75±5.01	0.20±0.01	7.72±0.02	4.08±0.2	3.64±0.18	1.12	55.80±0.95	0.68±0.04
	0.50 g/kg^b	145.20±10.96^∗	65.60±1.35	287.60±3.02	0.20±0.02	7.16±0.05	4.22±0.03	2.94±0.06	1.45	56.20±0.03	0.68±0.11

∗Data presented as mean ± standard deviation (𝑛=5). Significantly different from control: 𝑃<0.05.
^aControl group received 1 mL distilled water.
^bSample group received three doses of green mussel formulation (2.0, 1.0, and 0.5 g/kg rat).
SGOT: serum glutamic oxaloacetic transaminase; SGPT: serum glutamic pyruvic transaminase; ALP: alkaline phosphatase; A/G ratio: albumin/globulin ratio.