TY - JOUR A2 - Mastropasqua, Leonardo AU - Ambrosone, Luigi AU - Guerra, Germano AU - Cinelli, Mariapia AU - Filippelli, Mariaelena AU - Mosca, Monica AU - Vizzarri, Francesco AU - Giorgio, Dario AU - Costagliola, Ciro PY - 2014 DA - 2014/08/06 TI - Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops SP - 471642 VL - 2014 AB - Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays. SN - 2314-6133 UR - https://doi.org/10.1155/2014/471642 DO - 10.1155/2014/471642 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -