Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis

Table 7

Brain areas with reduced GM volume in ALS patients with left limb-onset and corresponding normal controls (𝑃<0.001, uncorrected).

Brain anatomical regions	BA; region	MNI coordinates of; peak voxels (mm)			Cluster; size	𝑇 value	𝑃 value
		𝑋	𝑌	𝑍
R_precentral gyri	4, 6	10	−18	48	89	4.07	0.0008
R_superior frontal gyri	6	14	−2	62	209	3.70	0.0008
R_supplementary motor areas	6	12	−6	58	28	3.42	0.0002
R_postcentral gyri	3	36	−28	42	33	4.09	0.0008
R_supramarginal gyri	40	62	−40	22	26	2.12	0.0002
L_precentral gyri	4, 6	−34	−14	54	111	3.56	0.0004
L_parietal opercular		−52	−38	20	28	3.92	0.0002
L_supramarginal gyri	40	−54	−46	18	93	3.42	0.0002
L_angular gyri	39	−44	−52	12	48	3.36	0.0004

L: left; R: right.