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BioMed Research International
Volume 2014 (2014), Article ID 474108, 6 pages
Research Article

Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

1Department of Dermatology, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil 5618953141, Iran
2Department of Midwifery, Islamic Azad University, Ardabil branch, Ardabil 5615731567, Iran
3Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil 5618953141, Iran

Received 6 February 2014; Accepted 14 July 2014; Published 24 July 2014

Academic Editor: Marian K. Malde

Copyright © 2014 Majid Rostami Mogaddam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant ( ). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.