Individual Subject Meta-Analysis of Parameters for Giardia duodenalis Shedding in Animal Experimental Models

Table 2

Studies included for Giardia duodenalis meta-analysis of diarrhoea (D) and shedding (S) outcomes (chronological order).

Reference	Year	Outcome	Sample size (number of animals)
			IS^1	P^2	ST^3	ES^4	A^5	IS^6	GD^7	AR^8	DM^9
[23]	1978	S^10	20	20	20	20	20	20	20	20	20
[24]	1979	S^10	47	47	NR^11	47	47	47	47	47	NR^11
[17]	1982	S^10	11	11	11	11	11	11	11	11	NR^11
[19]	1982	S^10	150	150	150	150	150	150	150	150	150
[25]	1984	S^10	49	49	NR^11	49	49	49	49	49	NR^11
[26]	1985	S^10	25	25	14	25	NR^11	25	25	25	25
[18]	1986	S^10	60	60	NR^11	60	49	60	60	60	60
[27]	1988	S^10	204	204	107	204	204	204	204	204	204
[28]	1989	S^10	10	10	NR^11	10	NR^11	10	10	10	10
[29]	1990	S^10	75	75	NR^11	75	75	75	75	75	75
[30]	1991	S^10	NR^11	NR^11	NR^11	10	10	10	10	10	10
[31]	1991	S^10	109	109	109	109	109	109	109	109	109
[32]	1992	S^10	NR^11	14	NR^11	14	14	14	14	14	14
[33]	1993	S^10	62	62	NR^11	62	62	62	62	62	62
[34]	1994	S^10	4	16	NR^11	16	16	16	16	NR^11	16
[35]	1996	S^10	10	10	10	10	10	10	10	10	10
[36]	1997	S^10	NR^11	10	NR^11	10	10	10	10	10	10
[37]	2002	S^10	NR^11	94	NR^11	94	94	94	94	94	94
[38]	2005	S^10	56	56	NR^11	56	56	56	56	56	56
[39]	2006	S^10	NR^11	6	NR^11	6	6	6	6	6	6
[40]	2007	S^10	97	97	97	97	97	97	97	97	97
[41]	2007	S^10	6	6	NR^11	6	6	6	6	6	6
[42]	2008	S^10	NR^11	12	NR^11	12	12	12	12	12	12
[43]	2008	S^10	NR^11	60	NR^11	60	60	60	60	60	60
[44]	2010	S^10	40	40	NR^11	40	40	40	40	40	40
[45]	2010	S^10	33	33	33	33	33	33	33	33	33
[46]	1995	S and D^12	70^13, 28^14	70^13, 28^14	30^13, 8^14	70^13, 28^14	70^13, 28^14	70^13, 28^14	70^13, 28^14	40^13, 20^14	70^13, NA^15
[47]	1995	S and D^12	52^13, 30^14	52^13, 30^14	22^13, NR^11	52^13, 30^14	52^13, 30^14	52^13, 30^14	52^13, 30^14	52^13, 30^14	52^13, NA^15
[48]	1997	S and D^12	10^16	10^16	NR^11	10^16	10^16	10^16	10^16	10^16	NA^15
[49]	2010	S and D^12	14^16	14^16	NR^11	14^16	14^16	14^16	14^16	14^16	NA^15

1Isolate Source, ²Passage, ³Storage Time (weeks), ⁴Experimental Species, ⁵Age, ⁶Infective Stage, ⁷Giardia Dose, ⁸Administration Route, ⁹Detection Method, ¹⁰Shedding outcome, ¹¹Information was not reported in study; thus no individual data were included, ¹²Shedding and Diarrhoea outcome, ¹³Number of individuals for shedding outcome, ¹⁴Number of individuals for diarrhoea outcome, ¹⁵Does not apply, ¹⁶Number of individuals for both outcomes.