Research Article
A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy
Table 1
Clinicopathologic variables and their association with the incidence of invasion detected in the surgical specimen on univariate analysis.
| Variable | Category | Number of patients with pure DCIS (%), | Number of patients with detected invasion in the resection specimen (%), | Odds ratio (95% CI) | Significance ( value) |
| Age, | >60 years ≤60 years | 83 (61.9) 148 (68.8) | 51 (38.1) 67 (31.2) | 1.357 (0.863, 2.134) | 0.202 |
| Palpability of the lesion, | Palpable Not palpable | 53 (49.5) 177 (73.4) | 54 (50.5) 64 (26.6) | 2.818 (1.753, 4.530) | <0.001 |
| Characteristics of the lesion on mammography, | Mass or distortion Microcalcifications (only) | 50 (66.7) 169 (68.4) | 25 (33.3) 78 (31.6) | 1.083 (0.625, 1.878) | 0.779 |
| Size of the lesion on mammography, | >30 mm ≤30 mm | 55 (55.6) 142 (74.3) | 44 (44.4) 49 (25.7) | 2.318 (1.389, 3.870) | 0.001 |
| Visibility of the lesion (mammographically detected) on ultrasonography, | Visible Not visible | 116 (58.6) 44 (84.6) | 82 (41.4) 8 (15.4) | 3.888 (1.739, 8.693) | <0.001 |
| Biopsy device, | 14-Gauge automated 11-Gauge vacuum assisted biopsy | 177 (66.0) 37 (72.5) | 91 (34.0) 14 (27.5) | 1.359 (0.699, 2.642) | 0.419 |
| Image guidance, | Ultrasonographic Stereotactic | 64 (56.1) 150 (73.2) | 50 (43.9) 55 (26.8) | 2.131 (1.316, 3.450) | 0.003 |
| Histologic grade (in the biopsy specimen), | High-grade Nonhigh-grade | 93 (61.6) 126 (72.8) | 58 (38.4) 47 (27.2) | 1.672 (1.046, 2.672) | 0.033 |
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Suspect (micro)invasion in the biopsy specimen, | Present Absent or not mentioned | 19 (36.5) 212 (71.4) | 33 (63.5) 85 (28.6) | 4.332 (2.335, 8.036) | <0.001 |
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