A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis

Table 3

Comparing rs2229238 polymorphisms in controls with those in TB cases.

(a) Analysis of the inheritance models of IL-6R rs2229238 polymorphism in the combined samples

Model	Genotype	TB (𝑛, %)	Control (𝑛, %)	𝑃 value	OR (95% CI)
Dominant	CC	309, 87.5	314, 78.7	0.001	0.53 (0.35–0.78)
	TC + TT	85, 21.3	44, 12.5
Recessive	CC + TC	351, 99.4	397, 99.5	0.9	1.13 (0.16–8.07)
	TT	2, 0.6	2, 0.5

(b) Comparison of the genotypes and alleles distribution in different patient subgroups stratified by diagnosis

Subjects (𝑛)*	Genotype (𝑛, %)		𝑃^1	OR^1 (95% CI)	Allele (𝑛, %)		𝑃^2	OR^2 (95% CI)
	TC + TT	CC			T	C
Control (400)	85, 21.3	314, 78.7	—		87, 10.9	711, 89.1	—
TB (273)	44, 12.5	309, 87.5	0.004	0.53 (0.35–0.78)	46, 6.5	660, 93.5	0.003	0.57 (0.39–0.83)
PTB (156)	23, 14.7	133, 85.3	0.073	0.64 (0.39–1.06)	24, 7.7	288, 92.3	0.109	0.68 (0.42–1.09)
EPTB (197)	21, 10.7	176, 89.3	0.004	0.44 (0.26–0.74)	22, 5.6	372, 94.4	0.003	0.48 (0.30–0.78)

∗PTB: pulmonary tuberculosis; EPTB: extrapulmonary. ¹𝑃 value and OR (95% CI) of 2×2  𝜒² test for dominant inheritance of T allele; ²𝑃 value and OR (95% CI) of 2×2  𝜒² tests for allele. ¹OR (95% CI) for dominant inheritance of T allele. ²OR (95% CI).