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BioMed Research International
Volume 2014, Article ID 484161, 8 pages
http://dx.doi.org/10.1155/2014/484161
Research Article

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

1Department of Neurosurgery, Mackay Memorial Hospital, Taipei 104, Taiwan
2Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan
3Department of Cardiology, College of Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
4Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
5Department of Neurosurgery, College of Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan
6Department of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, Shanghai, China

Received 16 January 2014; Accepted 6 February 2014; Published 17 March 2014

Academic Editor: Juei-Tang Cheng

Copyright © 2014 Cheng-Chia Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study investigated the merit of ginseng in the improvement of heart failure in diabetic rats and the role of peroxisome proliferator-activated receptors δ (PPARδ). We used streptozotocin-induced diabetic rat (STZ-rat) to screen the effects of ginseng on cardiac performance and PPARδ expression. Changes of body weight, water intake, and food intake were compared in three groups of age-matched rats; the normal control (Wistar rats) received vehicle, STZ-rats received vehicle and ginseng-treated STZ-rats. We also determined cardiac performances in addition to blood glucose level in these animals. The protein levels of PPARδ in hearts were identified using Western blotting analysis. In STZ-rats, cardiac performances were decreased but the food intake, water intake, and blood glucose were higher than the vehicle-treated control. After a 7-day treatment of ginseng in STZ-rats, cardiac output was markedly enhanced without changes in diabetic parameters. This treatment with ginseng also increased the PPARδ expression in hearts of STZ-rats. The related signal of cardiac contractility, troponin I phosphorylation, was also raised. Ginseng-induced increasing of cardiac output was reversed by the cotreatment with PPARδ antagonist GSK0660. Thus, we suggest that ginseng could improve heart failure through the increased PPARδ expression in STZ-rats.