[Retracted] MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target

Table 1

Downregulated tumor-suppressing miRNAs in HCC.

miRNA	Target genes	Characteristics	References
MiR-1	c-Met, ET-1	Metastasis, proliferation	[41]
MiR-7	PIK3CD, mTOR, p70S6K	Tumorigenesis, metastasis	[42]
MiR-26a	CDK6, cyclin D1	Cell cycle	[43, 44]
MiR-29	Bcl-2, Bcl-w, Ras	Apoptosis	[45, 46]
MiR-34a	cyclin D1, CDK4, and CDK2, c-Met	Cell cycle, proliferation, apoptosis, metastasis	[47, 48]
MiR-122	cyclin G1, Bcl-w, TACE	Apoptosis, angiogenesis, metastasis	[49–51]
MiR-124	ROCK2, EZH2	Metastasis	[52]
MiR-125b	Bcl-2, Bcl-w	Apoptosis	[53]
MiR-126	VEGF, VCAM-1	Angiogenesis, metastasis	[54–56]
MiR-141	EMT	Metastasis	[57, 58]
MiR-146a	TRAF6, IRAK1	Metastasis	[59]
MiR-195	CDK6, cyclin D1	Cell cycle, apoptosis	[43, 44]
MiR-198	c-Met	Metastasis	[60]
MiR-199a	mTOR, PAK4	Cell growth, apoptosis	[61–63]
MiR-200	EMT	Metastasis	[57, 58]
MiR-449	c-Met	Metastasis	[64]

ET1: endothelin-1.