TY - JOUR
A2 - Canducci, Filippo
AU - Salahuddin,
AU - Mazumder, Avijit
AU - Shaharyar, Mohammad
PY - 2014
DA - 2014/08/10
TI - Synthesis, Characterization, and In Vitro Anticancer Evaluation of Novel 2,5-Disubstituted 1,3,4-Oxadiazole Analogue
SP - 491492
VL - 2014
AB - In this series, we have synthesised a new 2,5-disubstituted 1,3,4-oxadiazole in search of potential therapeutics for cancer. The anticancer activities were evaluated on a panel of 60 cell lines by the National Cancer Institute according to its own screening protocol. Out of the 24 compounds, 11 were selected and evaluated via single high dose (10−5 M). In the next phase, two compounds have been selected for five-dose assay. The compounds 3-(5-benzyl-1,3,4-oxadiazol-2-yl)quinolin-2(1H)-one 18 (NSC-776965) and 3-[5-(2-phenoxymethyl-benzoimidazol-1-ylmethyl)-[1,3,4]oxadiazol-2-yl]-2-p-tolyloxy-quinoline 27 (NSC-776971) showed mean growth percentage of 66.23 and 46.61, respectively, in one-dose assay and their GI50 values ranging between 1.41–15.8 μM and 0.40–14.9 μM, respectively, in 5-dose assay.
SN - 2314-6133
UR - https://doi.org/10.1155/2014/491492
DO - 10.1155/2014/491492
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -