Research Article

Extended Renal Outcomes with Use of Iodixanol versus Iohexol after Coronary Angiography

Table 3

Multivariate analysis of renal dysfunction over one year after angiography (cohort A).

Significant variablesMultivariate linear regressionMultivariate logistic regression
(log-transformed %ΔCr + constant
as dependent variable)
(RIFLE “R/I/F” as dependent variable)
Coefficient95% CI valueOdds ratio95% CI value

Renal dysfunction at 3 days after contrast
 Age > 65 yrs (Y/N)0.050.01–0.090.021.881.11–3.210.02
 Male gender (vs female)−0.05−0.09–−0.010.020.400.24–0.670.001
 CCF (Y/N)0.070.01–0.140.032.621.35–5.080.004
 Baseline eGFR < 45−0.09−0.15–−0.020.009
 STEMI (Y/N)0.070.02–0.120.0072.081.11–3.890.02
 Valvular HD or septal defect (Y/N)0.140.02–0.270.037.672.18–27.040.002
 Critical illness (Y/N)0.210.14–0.27<0.0014.452.18–9.08<0.001
 IABP (Y/N)0.430.25–0.62<0.00117.661.80–173.550.01
 PCI (Y/N)0.050.00–0.090.04
 Aortogram (Y/N)0.080.00–0.160.04
 Iodine dose per unit eGFR > 0.7−0.08−0.12–−0.04<0.0010.500.29–0.860.01
Renal dysfunction at 30 days after contrast*
 CI-AKI (Y/N)0.300.13–0.470.00112.752.31–70.500.004
 Baseline eGFR < 450.050.00–0.800.04
 Hypertensive HD (Y/N)0.160.01–0.300.033.821.05–13.970.04
 Valvular HD or septal defect (Y/N)0.300.04–0.570.03
 Aortogram (Y/N)16.451.81–149.510.01
 Iodine dose per unit eGFR > 0.7−0.20−0.34–−0.060.0070.080.02–0.330.001
Renal dysfunction at 6 months after contrast*
 CI-AKI (Y/N)0.390.26–0.52<0.00115.313.03–77.350.001
 Suspect CAD without AMI (Y/N)0.180.06–0.300.003
 IABP (Y/N)−0.74−1.24–−0.250.004
 PCI (Y/N)−0.18−0.30–−0.070.003
 Aortogram (Y/N)0.250.05–0.450.01
Renal dysfunction at 1 year after contrast*
 CI-AKI (Y/N)0.280.02–0.530.03

Variables included in multivariate models include baseline variables: age > 65 yrs; male gender (vs females); DM (y/n); hypertensive HD (y/n); CCF (y/n); baseline eGFR < 45 mL/min/1.73 m2; suspect CAD without AMI (y/n); STEMI (y/n); NSTEMI (y/n); arrhythmias (y/n); valvular HD or septal defect (y/n); CMP (y/n) and periprocedure variables: COROS (y/n); aortogram (y/n); PCI (y/n); LVgram (y/n); IABP (y/n); iohexol use (vs iodixanol); iodine dose per unit eGFR > 0.7; critical illness within 1 wk after contrast (y/n).
*Additional variables added to model: CI-AKI (y/n); ΔCr > 26 μmol/L (0.3 mg/dL) at 3 days after contrast.
Delta-Cr expressed as % change from baseline Cr, with addition of constant (100), and log-transformed prior to linear regression.
ΔCr: (delta) change in Cr; AMI: acute myocardial infarction; CAD: coronary artery disease; CCF: congestive cardiac failure; CI: confidence interval; CMP: cardiomyopathy; COROS: coronary angiogram; Cr: serum creatinine; DM: diabetes mellitus; eGFR: estimated glomerular filtration rate; HD: heart disease; IABP: intra-aortic balloon pump; LVgram: left ventriculogram; NSTEMI: non-STEMI; PCI: percutaneous coronary intervention; STEMI: ST elevation myocardial infarction; vs: versus; wk: week; yrs: years.