Research Article
Extended Renal Outcomes with Use of Iodixanol versus Iohexol after Coronary Angiography
Table 3
Multivariate analysis of renal dysfunction over one year after angiography (cohort A).
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Significant variables | Multivariate linear regression | Multivariate logistic regression |
(log-transformed %ΔCr + constant as dependent variable†) | (RIFLE “R/I/F” as dependent variable) | Coefficient | 95% CI | value | Odds ratio | 95% CI | value |
| Renal dysfunction at 3 days after contrast | | | | | | | Age > 65 yrs (Y/N) | 0.05 | 0.01–0.09 | 0.02 | 1.88 | 1.11–3.21 | 0.02 | Male gender (vs female) | −0.05 | −0.09–−0.01 | 0.02 | 0.40 | 0.24–0.67 | 0.001 | CCF (Y/N) | 0.07 | 0.01–0.14 | 0.03 | 2.62 | 1.35–5.08 | 0.004 | Baseline eGFR < 45 | −0.09 | −0.15–−0.02 | 0.009 | | | | STEMI (Y/N) | 0.07 | 0.02–0.12 | 0.007 | 2.08 | 1.11–3.89 | 0.02 | Valvular HD or septal defect (Y/N) | 0.14 | 0.02–0.27 | 0.03 | 7.67 | 2.18–27.04 | 0.002 | Critical illness (Y/N) | 0.21 | 0.14–0.27 | <0.001 | 4.45 | 2.18–9.08 | <0.001 | IABP (Y/N) | 0.43 | 0.25–0.62 | <0.001 | 17.66 | 1.80–173.55 | 0.01 | PCI (Y/N) | 0.05 | 0.00–0.09 | 0.04 | | | | Aortogram (Y/N) | 0.08 | 0.00–0.16 | 0.04 | | | | Iodine dose per unit eGFR > 0.7 | −0.08 | −0.12–−0.04 | <0.001 | 0.50 | 0.29–0.86 | 0.01 | Renal dysfunction at 30 days after contrast* | | | | | | | CI-AKI (Y/N) | 0.30 | 0.13–0.47 | 0.001 | 12.75 | 2.31–70.50 | 0.004 | Baseline eGFR < 45 | | | | 0.05 | 0.00–0.80 | 0.04 | Hypertensive HD (Y/N) | 0.16 | 0.01–0.30 | 0.03 | 3.82 | 1.05–13.97 | 0.04 | Valvular HD or septal defect (Y/N) | 0.30 | 0.04–0.57 | 0.03 | | | | Aortogram (Y/N) | | | | 16.45 | 1.81–149.51 | 0.01 | Iodine dose per unit eGFR > 0.7 | −0.20 | −0.34–−0.06 | 0.007 | 0.08 | 0.02–0.33 | 0.001 | Renal dysfunction at 6 months after contrast* | | | | | | | CI-AKI (Y/N) | 0.39 | 0.26–0.52 | <0.001 | 15.31 | 3.03–77.35 | 0.001 | Suspect CAD without AMI (Y/N) | 0.18 | 0.06–0.30 | 0.003 | | | | IABP (Y/N) | −0.74 | −1.24–−0.25 | 0.004 | | | | PCI (Y/N) | −0.18 | −0.30–−0.07 | 0.003 | | | | Aortogram (Y/N) | 0.25 | 0.05–0.45 | 0.01 | | | | Renal dysfunction at 1 year after contrast* | | | | | | | CI-AKI (Y/N) | 0.28 | 0.02–0.53 | 0.03 | | | |
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Variables included in multivariate models include baseline variables: age > 65 yrs; male gender (vs females); DM (y/n); hypertensive HD (y/n); CCF (y/n); baseline eGFR < 45 mL/min/1.73 m2; suspect CAD without AMI (y/n); STEMI (y/n); NSTEMI (y/n); arrhythmias (y/n); valvular HD or septal defect (y/n); CMP (y/n) and periprocedure variables: COROS (y/n); aortogram (y/n); PCI (y/n); LVgram (y/n); IABP (y/n); iohexol use (vs iodixanol); iodine dose per unit eGFR > 0.7; critical illness within 1 wk after contrast (y/n).
*Additional variables added to model: CI-AKI (y/n); ΔCr > 26 μmol/L (0.3 mg/dL) at 3 days after contrast. †Delta-Cr expressed as % change from baseline Cr, with addition of constant (100), and log-transformed prior to linear regression. ΔCr: (delta) change in Cr; AMI: acute myocardial infarction; CAD: coronary artery disease; CCF: congestive cardiac failure; CI: confidence interval; CMP: cardiomyopathy; COROS: coronary angiogram; Cr: serum creatinine; DM: diabetes mellitus; eGFR: estimated glomerular filtration rate; HD: heart disease; IABP: intra-aortic balloon pump; LVgram: left ventriculogram; NSTEMI: non-STEMI; PCI: percutaneous coronary intervention; STEMI: ST elevation myocardial infarction; vs: versus; wk: week; yrs: years.
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