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BioMed Research International
Volume 2014, Article ID 512831, 14 pages
Review Article

Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

1Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic
2ICRC, St. Anne’s University Hospital, 60200 Brno, Czech Republic
3INSERM U1046, University of Montpellier I, University of Montpellier II, 34295 Montpellier, France

Received 6 December 2013; Accepted 4 February 2014; Published 2 April 2014

Academic Editor: Giancarlo Forte

Copyright © 2014 Ivana Acimovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).