Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma

Table 2

Comparison of measured plasma OPN and VEGF levels with clinical parameters in patients with MM.

Durie-Salmon stage

𝑃 value

Bone lesions

𝑃 value

Anemia

𝑃 value

Renal dysfunction

𝑃 value

I, II

III

Yes

No

Yes

No

Yes

No

OPN (ng/mL)

Median

5.65

8.9

0.05

7.4

2.8

0.03

7.6

6.6

0.29

12.6

7.05

0.13

Range

0.3–14.6

2.2–26.5

3.3–26.5

0.3–12.9

0.3–26.5

2.3–12.9

3.7–26.5

0.3–22.2

VEGF (pg/mL)

Median

35.9

60.15

0.04

48.1

55.75

0.79

57.4

47

0.43

46.9

59

0.51

Range

5.3–111.7

20.3–178.9

5.3–178.9

22.6–111.7

5.3–178.9

29.2–69.2

20.3–148.9

5.3–178.9