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BioMed Research International
Volume 2014, Article ID 514782, 7 pages
Research Article

Vitamin D Status in Migraine Patients: A Case-Control Study

1Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran
2Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran
3Medical Student Research Center, Faculty of Medicine, Islamic Azad University, NajafAbad Branch, NajafAbad 8514143131, Iran
4Department of Neurology and Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Hezarjarib Avenue, Isfahan 81745-319, Iran

Received 4 August 2013; Revised 10 October 2013; Accepted 16 October 2013; Published 2 January 2014

Academic Editor: Alessandro Landi

Copyright © 2014 Alireza Zandifar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. There have been few studies on the relation between vitamin D and migraine. We investigated the prevalence of vitamin D deficiency in migraine patients and compared it with a control group. We also evaluated the relationship of vitamin D deficiency with severity of migraine. Methods. 105 newly diagnosed migraine patients and 110 controls, matched for age, sex, socioeconomic status, education, and sun exposure, were enrolled during the spring of 2011. 25-Hydroxy vitamin D [25(OH)D] plasma levels were measured by chemiluminescence immunoassay. Results. The mean ± SE concentration of 25(OH)D was  ng/mL in cases and  ng/mL in controls. There was no significant difference in 25(OH)D concentration between cases and controls. We found no relationship between severity of headache and 25(OH)D status. Conclusions. We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level. Further studies with larger sample sizes are required to confirm our results.