Research Article
Vitamin D Status in Migraine Patients: A Case-Control Study
Table 4
Summary of the literature on relation between vitamin D and headache.
| | The first author (year) | Study design | Patient sample size | Type of headache | Headache severity assessment | Methods of vitamin D level assessment | Mean of vitamin D level in patient (ng/mL) | Effect/association of vitamin D (found by authors) |
| |
Kjaergaard et al. [28] (2012) | Cross-sectional | 4061 | Migraine () Nonmigraine headache () | Yes | Electrochemiluminescent immunometric
assay | 24.62
(migraine patient)
24.48 (nonmigraine headache) | Not associated | |
Knutsen et al. [33] (2010) | Cross-sectional | 63 | Patients with chief complaint of headache | Yes | High-pressure liquid chromatography
mass spectrometry
(HPLC-MS) | 14 | Associated | |
O’Brien et al. [29] (2010) | Cross-sectional | 300 | Episodic migraine () Chronic migraine () | No | Not reported | 24.19
(episodic migraine)
23.19 (chronic migraine) | Associated | |
Krusz et al. [30] (2010) | Cross-sectional | 100 | Migraine/ headache () pain syndromes () | No | Not reported | 29.3
(migraine/
headache)
28.2 (pain syndromes) | Not associated | | Wheeler [14] (2008) | Cross-sectional | 54 | Chronic migraine | No | Not reported | 34.6 | Associated | | Prakash [17] (2009) | Case report | 8 | Chronic tension-type headache | No | Not reported | 7 | Effective | | Thys-Jacobs [15] (November 1994) | Case report | 2 | Migraine | Yes | Not reported | Not reported | Effective | | Thys-Jacobs [16] (October 1994) | Case report | 2 | Menstrually-related migraines | Yes | Not reported | Not reported | Effective |
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