BioMed Research International / 2014 / Article / Fig 1

Review Article

Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease

Figure 1

Heparan sulfate (HS) is involved in essentially each step of amyloid- (A ) pathological development in Alzheimer’s disease. HS modulates -secretase (BACE) activity and accelerates A aggregation and fibrillization. It is unclear whether HS is involved in formation of the toxic oligomers/protofibrils; however, HS mediates toxic effect of different types of A fibrils. HS in the basement membrane participates in clearance of A .
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