Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins

Table 2

Antitumor activity and hepatotoxicity (GI₅₀, 𝜇g/mL) of different extracts of Laurus nobilis. The results are presented as mean ± SD¹.

	MCF7	NCI-H460	HCT15	HeLa	HepG2	PLP2-hepatotoxicity
Origin (O)
Cultivated	187±12^a	83±13	56±1	119±21	185±7	195±85
Wild	88±5^b	73±19	44±7	69±9	166±59	114±29
𝑃 value (𝑛=18)	<0.001	0.077	<0.001	<0.001	0.171	<0.001
Extract (E)
Methanolic	140±50	74±21	47±10	100±41	207±17	99±14
Aqueous	135±53	81±10	53±2	88±11	144±37	210±70
𝑃 value (𝑛=18)	0.773	0.254	0.011	0.242	<0.001	<0.001
O×E
𝑃 value (𝑛=36)	0.261	<0.001	<0.001	<0.001	<0.001	<0.001
Ellipticine	0.91±0.04	1.42±0.01	1.91±0.05	1.14±0.05	3.2±0.5	2.06±0.03

1Means within a column with different letters differ significantly (𝑃<0.001).