Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins

Table 4

Antifungal activity (MIC and MFC, mg/mL) of different extracts of Laurus nobilis. The results are presented as mean ± SD¹.

	Aspergillus fumigatus	Aspergillus versicolor	Aspergillus ochraceus	Aspergillus niger	Trichoderma viride	Penicillium funiculosum	Penicillium   ochrochloron	Penicillium verrucosum
MIC
Origin (O)
Cultivated	0.07±0.05	0.01±0.01	0.04±0.01	0.3±0.2	0.02±0.01	0.03±0.01	0.12±0.02	0.17±0.05
Wild	0.2±0.1	0.02±0.01	0.048±0.004	0.3±0.2	0.02±0.01	0.03±0.02	0.11±0.02	0.20±0.02
𝑃 value (𝑛=18)	<0.001	0.005	<0.001	0.603	0.163	0.407	0.054	0.005
Extract (E)
Methanolic	0.2±0.1	0.009±0.003	0.04±0.01	0.47±0.01	0.008±0.005	0.017±0.005	0.10±0.01	0.20±0.02
Aqueous	0.06±0.04	0.024±0.005	0.045±0.002	0.07±0.04	0.029±0.002	0.048±0.002	0.12±0.02	0.17±0.05
𝑃 value (𝑛=18)	<0.001	<0.001	0.077	<0.001	<0.001	<0.001	0.008	0.007
O×E
𝑃 value (𝑛=36)	<0.001	0.003	<0.001	<0.001	<0.001	<0.001	0.278	<0.001
Bifonazole	0.15±0.01	0.10±0.01	0.15±0.02	0.15±0.01	0.15±0.01	0.20±0.03	0.20±0.02	0.10±0.01
Ketoconazole	0.20±0.02	0.20±0.03	1.5±0.1	0.20±0.02	1.0±0.1	0.20±0.02	2.5±0.3	0.20±0.04
MFC
Origin (O)
Cultivated	0.2±0.1	0.05±0.03	0.08±0.03	0.4±0.4	0.03±0.01	0.10±0.02	0.23±0.02	0.6±0.3
Wild	0.4±0.1	0.04±0.01	0.11±0.01	0.5±0.3	0.03±0.02	0.11±0.02	0.20±0.02	0.40±0.03
𝑃 value (𝑛=18)	<0.001	0.091	<0.001	0.196	0.500	0.027	<0.001	0.041
Extract (E)
Methanolic	0.3±0.1	0.021±0.004	0.08±0.03	0.7±0.3	0.016±0.004	0.10±0.02	0.20±0.03	0.6±0.2
Aqueous	0.2±0.1	0.06±0.02	0.11±0.01	0.2±0.1	0.046±0.002	0.11±0.01	0.23±0.02	0.3±0.1
𝑃 value (𝑛=18)	<0.001	<0.001	<0.001	<0.001	<0.001	0.122	<0.001	<0.001
O×E
𝑃 value (𝑛=36)	0.001	<0.001	<0.001	0.312	<0.001	<0.001	0.052	<0.001
Bifonazole	0.20±0.02	0.20±0.03	0.20±0.01	0.20±0.02	0.20±0.04	0.25±0.05	0.25±0.04	0.20±0.03
Ketoconazole	0.50±0.05	0.50±0.04	2.0±0.4	0.50±0.05	1.0±0.1	0.50±0.04	3.5±0.5	0.30±0.05

1Means within a column with different letters differ significantly (𝑃<0.05).