Table of Contents Author Guidelines Submit a Manuscript
Corrigendum

A corrigendum for this article has been published. To view the corrigendum, please click here.

BioMed Research International
Volume 2014, Article ID 521794, 9 pages
http://dx.doi.org/10.1155/2014/521794
Research Article

Type 2C Phosphatase 1 of Artemisia annua L. Is a Negative Regulator of ABA Signaling

Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

Received 1 July 2014; Revised 27 August 2014; Accepted 29 August 2014; Published 28 October 2014

Academic Editor: Jose R. Botella

Copyright © 2014 Fangyuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. R. Cutler, P. L. Rodriguez, R. R. Finkelstein, and S. R. Abrams, “Abscisic acid: emergence of a core signaling network,” Annual Review of Plant Biology, vol. 61, pp. 651–679, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-K. Zhu, “Salt and drought stress signal transduction in plants,” Annual Review of Plant Biology, vol. 53, pp. 247–273, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Yoshida, Y. Fujita, H. Sayama et al., “AREB1, AREB2, and ABF3 are master transcription factors that cooperatively regulate ABRE-dependent ABA signaling involved in drought stress tolerance and require ABA for full activation,” Plant Journal, vol. 61, no. 4, pp. 672–685, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Ma, I. Szostkiewicz, A. Korte et al., “Regulators of PP2C phosphatase activity function as abscisic acid sensors,” Science, vol. 324, no. 5930, pp. 1064–1068, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Nishimura, A. Sarkeshik, K. Nito et al., “PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis,” Plant Journal, vol. 61, no. 2, pp. 290–299, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. F. F. Soon, L. M. Ng, X. E. Zhou et al., “Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases,” Science, vol. 335, no. 6064, pp. 85–88, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Brandt, D. E. Brodsky, S. Xue et al., “Reconstitution of abscisic acid activation of SLAC1 anion channel by CPK6 and OST1 kinases and branched ABI1 PP2C phosphatase action,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 26, pp. 10593–10598, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Umezawa, N. Sugiyama, M. Mizoguchi et al., “Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 41, pp. 17588–17593, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Xue, D. Wang, S. Zhang et al., “Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis,” BMC Genomics, vol. 9, article 550, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Antoni, M. Gonzalez-Guzman, L. Rodriguez, A. Rodrigues, G. A. Pizzio, and P. L. Rodriguez, “Selective inhibition of clade A phosphatases type 2C by PYR/PYL/RCAR abscisic acid receptors,” Plant Physiology, vol. 158, no. 2, pp. 970–980, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G. B. Bhaskara, T. T. Nguyen, and P. E. Verslues, “Unique drought resistance functions of the highly ABA-induced clade a protein phosphatase 2Cs,” Plant Physiology, vol. 160, no. 1, pp. 379–395, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Yoshida, T. Umezawa, T. Mizoguchi, S. Takahashi, F. Takahashi, and K. Shinozaki, “The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis,” Journal of Biological Chemistry, vol. 281, no. 8, pp. 5310–5318, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Merlot, F. Gosti, D. Guerrier, A. Vavasseur, and J. Giraudat, “The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway,” Plant Journal, vol. 25, no. 3, pp. 295–303, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. H.-F. Jia, D. Lu, J.-H. Sun et al., “Type 2C protein phosphatase ABI1 is a negative regulator of strawberry fruit ripening,” Journal of Experimental Botany, vol. 64, no. 6, pp. 1677–1687, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Kim, H. Hwang, J. W. Hong et al., “A rice orthologue of the ABA receptor, OsPYL/RCAR5, is a positive regulator of the ABA signal transduction pathway in seed germination and early seedling growth,” Journal of Experimental Botany, vol. 63, no. 2, pp. 1013–1024, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. O. Lorenzo, D. Rodríguez, G. Nicolás, P. L. Rodríguez, and C. Nicolás, “A new protein phosphatase 2C (FsPP2C1) induced by abscisic acid is specifically expressed in dormant beechnut seeds,” Plant Physiology, vol. 125, no. 4, pp. 1949–1956, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Saavedra, A. Modrego, D. Rodríguez et al., “The nuclear interactor PYL8/RCAR3 of Fagus sylvatica FsPP2C1 is a positive regulator of abscisic acid signaling in seeds and stress,” Plant Physiology, vol. 152, no. 1, pp. 133–150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Liu, X. Hu, J. Song, X. Zong, and D. Li, “Over-expression of a Zea mays L. protein phosphatase 2C gene (ZmPP2C) in Arabidopsis thaliana decreases tolerance to salt and drought,” Journal of Plant Physiology, vol. 166, no. 5, pp. 531–542, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Komatsu, Y. Nishikawa, T. Ohtsuka et al., “Functional analyses of the ABI1-related protein phosphatase type 2C reveal evolutionarily conserved regulation of abscisic acid signaling between Arabidopsis and the moss Physcomitrella patens,” Plant Molecular Biology, vol. 70, no. 3, pp. 327–340, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. L. A. Graham, K. Besser, S. Blumer et al., “The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin,” Science, vol. 327, no. 5963, pp. 328–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Wang, Y. Wang, Q. Zhang, Y. Qi, and D. Guo, “Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing,” BMC Genomics, vol. 10, article 465, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. R. Romero, M. A. Serrano, M. Vallejo, T. Efferth, M. Alvarez, and J. J. G. Marin, “Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV),” Planta Medica, vol. 72, no. 13, pp. 1169–1174, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Efferth, “Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells,” Current Drug Targets, vol. 7, no. 4, pp. 407–421, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Utzinger, S.-H. Xiao, M. Tanner, and J. Keiser, “Artemisinins for schistosomiasis and beyond,” Current Opinion in Investigational Drugs, vol. 8, no. 2, pp. 105–116, 2007. View at Google Scholar · View at Scopus
  25. F. Jing, L. Zhang, M. Li et al., “Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway,” Biologia, vol. 64, no. 2, pp. 319–323, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Zhang, X. Lu, Z. Lv et al., “Overexpression of the artemisia orthologue of ABA receptor, AaPYL9, enhances ABA sensitivity and improves artemisinin content in Artemisia annua L,” PLoS ONE, vol. 8, no. 2, Article ID e56697, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. K. W. Earley, J. R. Haag, O. Pontes et al., “Gateway-compatible vectors for plant functional genomics and proteomics,” Plant Journal, vol. 45, no. 4, pp. 616–629, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. Q. Lu, X. Tang, G. Tian et al., “Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin,” Plant Journal, vol. 61, no. 2, pp. 259–270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. S.-Y. Park, P. Fung, N. Nishimura et al., “Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins,” Science, vol. 324, no. 5930, pp. 1068–1071, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Schweighofer, H. Hirt, and I. Meskiene, “Plant PP2C phosphatases: Emerging functions in stress signaling,” Trends in Plant Science, vol. 9, no. 5, pp. 236–243, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. H.-L. Sun, X.-J. Wang, W.-H. Ding et al., “Identification of an important site for function of the type 2C protein phosphatase ABI2 in abscisic acid signalling in Arabidopsis,” Journal of Experimental Botany, vol. 62, no. 15, pp. 5713–5725, 2011. View at Publisher · View at Google Scholar · View at Scopus