## Computational and Theoretical Analysis of Human Diseases Associated with Infectious Pathogens

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Abdon Atangana, Suares Clovis Oukouomi Noutchie, "Model of Break-Bone Fever via Beta-Derivatives", *BioMed Research International*, vol. 2014, Article ID 523159, 10 pages, 2014. https://doi.org/10.1155/2014/523159

# Model of Break-Bone Fever via Beta-Derivatives

**Academic Editor:**TEWA Jean Jules

#### Abstract

Using the new derivative called beta-derivative, we modelled the well-known infectious disease called break-bone fever or the dengue fever. We presented the endemic equilibrium points under certain conditions of the physical parameters included in the model. We made use of an iteration method to solve the extended model. To show the efficiency of the method used, we have presented in detail the stability and the convergence of the method for solving the system (2). We presented the uniqueness of the special solution of system (2) and finally the numerical simulations were presented for various values of beta.

#### 1. Introduction

In the last two centuries, several new infectious diseases have been discovered. Their mode of transmission differs from one disease to another. In some cases the transmission is in direct contact with the patient; see, for instance, HIV. The transmission can also take place in air, for instance, TB. In other cases the transmission is indirect; the virus is transported by a vector such as a mosquito and others. One of these infectious diseases is the so-called dengue fever also known as break-bone fever. The first record of this infectious disease can be traced back in a Chinese medical instruction book from the Jin Dynasty (265–420° AD) which referred to a water poison associated with flying insects [1, 2]. The primary vector,* A. aegypti*, extended to Africa in the 15th to 19th centuries because of the increased globalization secondary to the slave trade [3]. In many years to follow, there have been metaphors of epidemics in the 17th century, other than the most credible premature reports of dengue epidemic are from 1779 and 1780, when an epidemic brushed away crosswise Asia, Africa, and North America [2].

This disease is transmitted by several species of mosquito within the genus* Aedes*, principally* A. aegypti*. The virus has five different types; infection with one type usually gives lifelong immunity to that type, but only short term immunity to the others [4]. When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito saliva. It attaches to and enters white blood cells and duplicates inside the cells at the same time as they progress all the way through the body. In the process of defense, the white blood cells take action by producing a number of signalling proteins, such as cytokines and interferons, which are responsible for many symptoms. This mechanism can be converted in mathematical equations.

SEIR model is one mathematical equation underpinning the analysis of the simulation of the spread of dengue virus between host and vector. A well-established knowledge regarding the mathematical formulation of the model for the human and mosquito populations can be found in [5] and is given as where is the host population, and are the death rate of host and vector populations, respectively, and are the transmission probability from vector to host and from host to vector, respectively, is the biting rate of the vector, and are infected vector and host population, respectively, is the number of susceptible persons in the host population, is the recruitment rate of the vector host, is the recovery rate of the host population, is the proportional rate of the mosquitoes exposed to the virus infection, and is the rate of death caused by dengue fever. In the recent years scholars in the area of applications of ordinary and partial differential equations have paid their attentions to investigate which concept of derivative is suitable for modeling real world problems [5, 6]. The outcome of these investigations revealed that it is more suitable to model real world problems with derivative based on the fractional concept than the classical version. The derivative based on the concept of fractional order has therefore gained the world of modeling in the recent decade including in the field of hydrology studies, chemistry, engineering, and mathematical biology [7–12]. With the rewards of fractional derivatives, several new definitions have been introduced recently [13, 14]. In the same line of idea, we have put in place a new derivative called the -derivative; this derivative may not be seen as fractional derivative but has fractional compound [15, 16]. We have used this derivative in our previous work and the results obtained were very interesting. Therefore in this work our main interest is to extend (1) using the new derivative; a stability analysis will be presented and finally a special solution using some interesting iterations methods will be presented as well. The extended version of (1) is given by where for all , . When the limit of the above exists, is said to be -differentiable.

Theorem 1 (see [16]). *Assuming that is differential and -differentiable on the opened interval , then
*

*Definition 2 (see [16]). *Let be a given function; then we propose that the integral of order -integral of is
The above operator is the inverse operator of the proposed beta-derivative and is called the Atangana ‘beta integral.

#### 2. Endemic Equilibrium

In this section, we will present the endemic equilibrium points and also present the stability analysis. If we assume that the system of equations does not depend on time, beta-derivative allows us to have It is worth noting that there is no general solution of the above equation in the literature; therefore in this world we will provide a general solution of the above system under some condition on the physical parameters. Consider However, to find we will solve the following equation: Nonetheless, for simplicity, we put Then (8) can be converted to The solution of (10) is given as Now according to the physical meaning of our problem, we chose only the positive solution and we have the last equilibrium endemic point . The endemic equilibrium points are given as

#### 3. Method for Solving the System

One of the important aspects in modeling is not only to formulate the physical problem into a mathematical equation, but also to be able to predict the behaviour of this physical problem. This can only be achieved by finding the solution of the system. The problem under investigation is a nonlinear problem and needs an efficient analytical technique to derive a special solution of the system. In this paper we will use the so-called homotopy decomposition method to achieve this. The methodology of this technique can be found in several papers, for instance, in [17, 18]. But in this paper, we will only apply the method to solve the system (2). Therefore applying the method on system (2), we obtain the following iteration formulas: where

##### 3.1. Stability Analysis

Before the presentation of the stability, we will first present the following operator, which will be referred to as Atangana ‘beta inner product.

*Definition 3. *A function defined on [ ] is said to be beta-integrable if
exists.

*Definition 4. *Let and be two functions defined on . Assuming that is beta-integrable, then the beta inner product is defined as
We will present some properties of the above operator.

*Properties*(1): the operator is symmetric;(2), any constant in real space;(3) if or ;(4) if ;(5)if and are bounded and are positive functions in [0 ], then is bounded in [0 ].

*Proof. *Consider
implies that ; using the integral properties, we obtain for all in ; then for all in since ; thus, or for all in :
However, for all in , by applying integral sign we obtain
Assume that and are bounded in ; then we can find two real numbers, say and , such that for all in and ; this implies ; thus
With the above information in hand, we will now prove the stability of the method for solving the system (2). To achieve this, we will in addition consider the following operator:

Theorem 5. *Let us consider the operator and consider the initial and boundary condition for (2); then the new variation iteration method leads to a special solution of (2).*

*Proof. *To achieve this we will think about the following sub-Hilbert space of the Hilbert space [13] that can be defined as the set of those functions in the following space:
We harmoniously assume that the differential operators are restricted under the norms. Using the definition of the operator we have the following:
We will now evaluate the inner product of , :
We will evaluate the above row after row. Now using the properties of the inner function, we obtained the following:
Therefore, we have that
It follows that it is possible to find a positive such that
with and . We will prove that we can also find a positive constant such that for all
In fact,
Again, using a similar method that we used earlier, we obtain the following inequality:
Therefore
Inequalities (31) and (27) guaranty the stability of the method used to solve (2) and also lead us to a special solution of (2). We will now show in detail the uniqueness of the special solution.

##### 3.2. Uniqueness of the Special Solution

Theorem 6. *The special solution obtained via the used method is unique.*

*Proof. *Assuming that is the exact solution of system (2), let and be two different special solutions of system and converge to for some large numbers and (2) while using the homotopy method; then using Theorem 5, we have the following inequality:
Using the triangular inequality, we arrive at the following:
However, since and converge to for large numbers and , then we can find a small positive parameter , such that
Now consider ; then
Then borrowing the topology idea, we have that
Since and , then implying . This shows the uniqueness of the special solution.

##### 3.3. Algorithm

We will give the following code that will be used to derive the special solution of system (2):(i)input: as preliminary input;(ii): number of terms in the rough calculation;(iii)output: the approximate solution.

*Step 1. *Put

*Step 2. *For to do Step 3, Step 4, and Step 5:

*Step 3. *Compute

*Step 4. *Compute

*Step 5. *Compute
Stop.

The above algorithm will be used to derive the special solution of system (2).

#### 4. Numerical Solution

The above algorithm will be used to produce the numerical solution of system (2) for given values of parameters that can also be found in the literature. We chose the following: Now employing the above algorithm, we obtain Many other terms can be computed using the algorithm. The numerical simulations of the special solution for the first two components are depicted in Figures 1, 2, 3, 4, and 5. It is very clear from Figures 3, 4, and 5 that the model depends on the parameter beta; precisely, we observed that the set of solutions is much dependent on the parameter beta; as beta decreases, the set of numerical solutions also decreases.

#### 5. Conclusion

In the last decade mathematic tools have been used to model several physical phenomena, for instance, infectious diseases. These mathematical equations describing infectious diseases are using the idea of derivative. Nowadays there exist several derivatives in the literature; all of them have their strength and their weaknesses. For example, the fractional derivative according to Riemann-Liouville and Caputo is not obeying the product, quotient, and chain rule. A new derivative called beta-derivative was used to model the break-bone disease. The resulting system of equations was examined in the scope of an iteration method. For the first time, an analytical expression underpinning the endemic equilibrium points was presented. The efficacy of the used method was demonstrated via the stability and convergence analysis. A relatively new inner product was proposed and was used to prove the uniqueness of the special solution. Numerical simulations were depicted in Figures 1, 2, 3, 4, and 5 for a given value of beta. The derivative used here will shed light on the field of modeling.

#### Conflict of Interests

The authors declare that there is no conflict of interests for this paper.

#### Acknowledgment

Abdon Atangana would like to thank the Claude Leon Foundation for their financial support.

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#### Copyright

Copyright © 2014 Abdon Atangana and Suares Clovis Oukouomi Noutchie. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.