Table 3: Comparisons of degree of fibrosis, vascular densities, and inflammatory cells in explanted heart of minipigs without and with tacrolimus therapy.

Normal
Mean ± SD
InfarctPeri-infarct value*
Control
Mean ± SD
Tac-treated
Mean ± SD
Control
Mean ± SD
Tac-treated
Mean ± SD

Mean fibrotic areas (×104 m2/HPF)1.2 ± 0.1384.1 ± 8.9276.3 ± 23.631.5 ± 9.513.1 ± 0.5
= 0.013 = 0.002

Number of small vessels/HPF8.1 ± 0.42.5 ± 0.44.2 ± 0.44.8 ± 0.16.6 ± 0.5
= 0.031 = 0.023

% of CD68+ cells0.3 ± 0.08.0 ± 0.26.3 ± 0.23.7 ± 0.42.2 ± 0.5
= 0.019 = 0.027

% of CD40+ cells5.8 ± 1.268.8 ± 3.851.2 ± 2.947.1 ± 2.036.7 ± 2.4
= 0.021 = 0.031

HFP: high power field; value: normal remote myocardium versus other groups; , : comparisons in infarct and peri-infarct areas, respectively.
(Statistical analyses using one-way ANOVA followed by Tukey’s multiple comparison procedure with significance at 0.05 level).