Survey of Network-Based Approaches to Research of Cardiovascular Diseases

Figure 1

Using network topology to infer elements involved in disease. Panel (a): green node is associated with disease based on its neighbouring disease nodes (shown in red). Panel (b): nodes bordered in blue are part of the same cluster based on similar topology around them. Green node is associated with disease based on the cluster's enrichment in disease nodes (shown in red). Panel (c): nodes bordered in blue are part of the same graph cluster or community, in the network. Green nodes are associated with disease based on the community's enrichment in disease nodes (shown in red). Panel (d): node shown in green is associated with the disease, as a common node on shortest paths between nodes related to disease (shown in red).