Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity

Figure 4

Antioxidant parameters. (a) Nitrites, (b) superoxide scavenging activity (SOSA), (c) catalase, (d) total antioxidant capacity (TAC), and (e) thiols on plasma from Wistar Kyoto control rats (WKY, 𝑛=6), spontaneously hypertensive control rats (SHR, 𝑛=6), and spontaneously hypertensive rat treated with esmolol (SHR-E, 𝑛=6). Data are expressed as mean ± SEM. Statistically significant differences between WKY, SHR, and SHR-E are shown (^∗𝑃<0.05 versus WKY; ^∗∗𝑃<0.01 versus WKY; ^∗∗∗𝑃<0.001 versus WKY; ^##𝑃<0.01 versus SHR; ^###𝑃<0.001 versus SHR).

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