IDH Mutations: Genotype-Phenotype Correlation and Prognostic Impact

Table 3

Multivariate Cox proportional hazards regression model analysis of survival of the 1305 glioma patients cohort. MGMT promoter methylation was not included in this analysis due to a low number of evaluable patients for this parameter.

Parameter	Overall survival			Progression free survival
	HR	95% CI for HR	𝑃	HR	95% CI for HR	𝑃
Age > 60 years	1.831	1.358 to 2.467	0.0001	1.479	1.158 to 1.889	0.0018
Surgery extent	0.775	0.588 to 1.021	0.0715	1.045	0.823 to 1.326	0.7199
1p19q codeletion	0.202	0.098 to 0.415	<0.0001	0.491	0.326 to 0.739	0.0007
IDH mutation	0.358	0.248 to 0.517	<0.0001	0.467	0.348 to 0.627	<0.0001
IK > 70	0.419	0.315 to 0.556	<0.0001	0.489	0.375 to 0.636	<0.0001
P16 deletion	1.513	1.168 to 1.960	0.0018	1.471	1.165 to 1.858	0.0013