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Retracted

BioMed Research International has retracted this article. As noted by Amanda Capes-Davis on PubMed Commons, KB cells are cross-contaminated by HeLa and are not oral cancer cells [2]. Therefore, the conclusions cannot be supported. Tan IIA was already known to induce apoptosis in HeLa cells through a mitochondria-dependent pathway [3].

View the full Retraction here.

References

  1. P.-Y. Tseng, W.-C. Lu, M.-J. Hsieh, S.-Y. Chien, and M.-K. Chen, “Tanshinone IIA induces apoptosis in human oral cancer KB cells through a mitochondria-dependent pathway,” BioMed Research International, vol. 2014, Article ID 540516, 7 pages, 2014.
  2. T. Chen, “Modal karyotype of human leukemia cell line, K562 (ATCC CCL 243),” Cancer Genetics and Cytogenetics, vol. 17, no. 1, pp. 55–60, 1985.
  3. L. Zhou, W. K. Chan, N. Xu et al., “Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest,” Life Sciences, vol. 83, no. 11-12, pp. 394–403, 2008.
BioMed Research International
Volume 2014, Article ID 540516, 7 pages
http://dx.doi.org/10.1155/2014/540516
Research Article

Tanshinone IIA Induces Apoptosis in Human Oral Cancer KB Cells through a Mitochondria-Dependent Pathway

1Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua 500, Taiwan
2Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
3Institute of Medicine, Chung Shan Medical University, Taichung 500, Taiwan
4School of Optometry, Chung Shan Medical University, Taichung 402, Taiwan
5Department of Pharmacy, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua 500, Taiwan
6School of Pharmacy, China Medical University, Taichung 404, Taiwan
7College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan

Received 26 February 2014; Accepted 12 April 2014; Published 13 May 2014

Academic Editor: Tsung-Lin Yang

Copyright © 2014 Pao-Yu Tseng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • M. Akaberi, S. Mehri, and M. Iranshahi, “Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species,” Fitoterapia, 2014. View at Publisher · View at Google Scholar
  • Lei Wan, Yang Zou, Li-Hui Wan, Li-Qun Wang, Mei-Zhen Huang, Juan Wu, Yi-Bao Zhu, and Ou-Ping Huang, “Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3ζ downregulation,” Archives of Gynecology and Obstetrics, vol. 292, no. 6, pp. 1301–1309, 2015. View at Publisher · View at Google Scholar
  • Yi Jin, Shizhu Chen, Jianlei Duan, Guang Jia, and Jinchao Zhang, “Europium-Doped Gd2O3 Nanotubes Cause the Necrosis of Primary Mouse Bone Marrow Stromal Cells through Lysosome and Mitochondrion Damage,” Journal of Inorganic Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Yan Zhong, Hiromasa Kiyota, Man-Li Zhang, Jin-Sheng Qi, and Qing-Wen Shi, “Research advances on biological activities of tanshinone IIA-a mini review,” Mini-Reviews in Organic Chemistry, vol. 13, no. 4, pp. 305–311, 2016. View at Publisher · View at Google Scholar
  • Xiaoping Jing, Yichun Xu, Weiwei Cheng, Sheng Guo, Ya Zou, and Li He, “Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers,” Cancer Chemotherapy And Pharmacology, vol. 77, no. 6, pp. 1171–1181, 2016. View at Publisher · View at Google Scholar
  • Eun-Ok Kim, Shi Eun Kang, Chang Rak Im, Jun-Hee Lee, Kwang Seok Ahn, Woong Mo Yang, Jae-Young Um, Seok-Geun Lee, and Miyong Yun, “Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction,” International Journal Of Oncology, vol. 48, no. 5, pp. 2205–2212, 2016. View at Publisher · View at Google Scholar
  • Yangqiu Bai, Lida Zhang, Xinhui Fang, and Yuxiu Yang, “Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-kappa B,” Experimental And Therapeutic Medicine, vol. 11, no. 3, pp. 1085–1089, 2016. View at Publisher · View at Google Scholar
  • Yu-Chiang Hung, Tai-Long Pan, and Wen-Long Hu, “ Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge ,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  • Sung-Ying Huang, Shu-Fang Chang, Kuan-Fu Liao, and Sheng-Chun Chiu, “Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling,” International Journal of Molecular Sciences, vol. 18, no. 8, pp. 1616, 2017. View at Publisher · View at Google Scholar
  • Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang, and Yuan-Wu Chen, “Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Andy Wei-Ge Chen, Yen-Shuo Tseng, Chia-Chieh Lin, Yi-Ting Hsi, Yu-Sheng Lo, Yi-Ching Chuang, Shu-Hui Lin, Chia-Yun Yu, Ming-Ju Hsieh, and Mu-Kuan Chen, “Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway,” Environmental Toxicology, 2017. View at Publisher · View at Google Scholar
  • Peipei Sun, Xin Zhou, Yingzhi He, Huimin Liu, Yuxin Wang, Yiran Chen, Meifang Li, Yanjie He, Guowei Li, and Yuhua Li, “Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway,” Biochemical and Biophysical Research Communications, 2018. View at Publisher · View at Google Scholar