BioMed Research International / 2014 / Article / Tab 1 / Review Article
Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster Table 1 Percentage of children reporting local symptoms during 4–15 days following booster vaccination.
Country and author
Age (years)
Vaccine Local symptoms (%) Pain Redness Swelling Functional impairment Any Grade 3* Any Grade 3 Any Grade 3**** Local Diffuse Adj. joint Any Grade 3
USA Black et al., 2008 [26 ]
4–6 DTaP − IPV 57.0 1.6 36.6 17.6** 26.0 10.2**** — — — — — DTaP + IPV 53.3 0.6 36.6 20.0** 27.0 11.5**** — — — — — India Bose et al., 2007 [24 ] 4–6 dTap 31.1 1.4 8.9 — 18.2 — — — — — — Taiwan Huang et al., 2005 [20 ] 6–8 dTap 66.7 0.0 35.0 0.0** 40.0 0.0 — — — — — Sweden, Italy Jacquet et al., 2006 [21 ] 4–7 DTaP − IPV 71.4 2.9 61.0 25.7** 53.3 13.3**** — — — — — Taiwan Lin et al., 2008 [28 ] 6–8 dTap − IPV 37.6 9.4 28.2 0.0*** 28.2 0.0*** — — — — —
Germany Meyer et al., 2008 [27 ]
4–6 dTap 47.8 1.1 33.9 13.3** 32.2 13.3**** — — — — — DTaP 63.3 2.2 48.9 23.3** 43.3 15.6**** — — — — — Thailand Pancharoen et al., 2012 [31 ] 4–6 DTaP − IPV 75.6 0.8 48.8 4.1** 36.6 2.4**** — — — — —
Australia Quinn et al., 2011 [30 ]
4–6 DTaP 47.4 4.3 86.9 86.9** 69.5 60.8**** 26.1 8.7 60.9 34.8 0.0 dTap 50.1 0.0 100 93.8** 81.3 75.0**** 56.3 18.8 25.0 18.8 0.0
Germany Sänger et al., 2007 [23 ]
4–8 dTap − IPV 55.7 2.8 53.2 10.6** 44.8 8.8**** 9.6 2.7 0.4 — — dTap − IPV 64.0 6.6 57.4 16.2** 54.4 14.0**** 9.6 3.7 1.5 — — China Zhu et al., 2010 [29 ] Study A 6–8 dTap 10.0 — 23.0 10.0** — — — — — — — China Zhu et al., 2010 [29 ] Study B 6–8 dTap DT 19.0 20.5 — — 14.5 15.5 — — 12.0 8.0 — — — — — — — — — — — —
Cries when limb is moved/spontaneously painful.
**Redness with diameter >50 mm.
***Redness/swelling with diameter >20 mm.
****Swelling with diameter >50 mm, or noticeable diffuse swelling, or noticeable increase of limb circumference.