Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster

Table 1

Percentage of children reporting local symptoms during 4–15 days following booster vaccination.

Country and author	Age (years)	Vaccine	Local symptoms (%)
			Pain		Redness		Swelling					Functional impairment
			Any	Grade 3*	Any	Grade 3	Any	Grade 3****	Local	Diffuse	Adj. joint	Any	Grade 3
USA; Black et al., 2008 [26]	4–6	DTaP − IPV	57.0	1.6	36.6	17.6**	26.0	10.2****	—	—	—	—	—
		DTaP + IPV	53.3	0.6	36.6	20.0**	27.0	11.5****	—	—	—	—	—
India; Bose et al., 2007 [24]	4–6	dTap	31.1	1.4	8.9	—	18.2	—	—	—	—	—	—
Taiwan; Huang et al., 2005 [20]	6–8	dTap	66.7	0.0	35.0	0.0**	40.0	0.0	—	—	—	—	—
Sweden, Italy; Jacquet et al., 2006 [21]	4–7	DTaP − IPV	71.4	2.9	61.0	25.7**	53.3	13.3****	—	—	—	—	—
Taiwan; Lin et al., 2008 [28]	6–8	dTap − IPV	37.6	9.4	28.2	0.0***	28.2	0.0***	—	—	—	—	—
Germany; Meyer et al., 2008 [27]	4–6	dTap	47.8	1.1	33.9	13.3**	32.2	13.3****	—	—	—	—	—
		DTaP	63.3	2.2	48.9	23.3**	43.3	15.6****	—	—	—	—	—
Thailand; Pancharoen et al., 2012 [31]	4–6	DTaP − IPV	75.6	0.8	48.8	4.1**	36.6	2.4****	—	—	—	—	—
Australia; Quinn et al., 2011 [30]	4–6	DTaP	47.4	4.3	86.9	86.9**	69.5	60.8****	26.1	8.7	60.9	34.8	0.0
		dTap	50.1	0.0	100	93.8**	81.3	75.0****	56.3	18.8	25.0	18.8	0.0
Germany; Sänger et al., 2007 [23]	4–8	dTap − IPV	55.7	2.8	53.2	10.6**	44.8	8.8****	9.6	2.7	0.4	—	—
		dTap − IPV	64.0	6.6	57.4	16.2**	54.4	14.0****	9.6	3.7	1.5	—	—
China; Zhu et al., 2010 [29]; Study A	6–8	dTap	10.0	—	23.0	10.0**	—	—	—	—	—	—	—
China; Zhu et al., 2010 [29]; Study B	6–8	dTap; DT	19.0; 20.5	—; —	14.5; 15.5	—; —	12.0; 8.0	—; —	—; —	—; —	—; —	—; —	—; —

∗Cries when limb is moved/spontaneously painful.
**Redness with diameter >50 mm.
***Redness/swelling with diameter >20 mm.
****Swelling with diameter >50 mm, or noticeable diffuse swelling, or noticeable increase of limb circumference.