Review Article
Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster
Table 2
Percentage of children reporting general symptoms during 4–15 days following booster vaccination.
|
Country and author |
Age (years) |
Vaccine | General symptoms (%) | Fever | Drowsiness | Fatigue | Malaise | Myalgia | Loss of appetite | Irritability |
Gastrointestinal (diarrhea) | Vomiting | Headache | ≥37.5°C | >39.0°C | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ ∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ | Any | Grade 3∧ |
| USA Black et al., 2008 [26] | 4–6 | DTaP − IPV DTaP + IPV | 16.0 14.8 | 1.1 1.1 | 19.1 17.5 | 0.8 0.8 | 16.7 — | 0.0 — | — — | — — | — — | — — | 15.5 16.0 | 0.8 0.6 | — — | — — | 6.7 — | 0.0 — | — — | — — | — — | — — |
| India Bose et al., 2007 [24] | 4–6 | dTap | 17.3 | 0.0 | 4.3 | 0.3 | — | — | — | — | — | — | 9.5 | 0.0 | 8.1 | 0.6 | — | — | — | — | — | — |
| Taiwan Huang et al., 2005 [20] | 6–8 | dTap | 0.0 | 0.0 | — | — | 16.7 | 0.0 | — | — | — | — | — | — | — | — | 6.7 | 0.0 | — | — | 10.0 | 0.0 |
| Sweden, Italy Jacquet et al., 2006 [21] | 4–7 | DTaP − IPV | 21.0 | 0.8 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Taiwan Lin et al., 2008 [28] | 6–8 | dTap − IPV | 11.8 | — | 10.6 | 0.0 | — | — | — | — | — | — | 12.9 | 0.0 | 5.9 | — | — | — | — | — | — | — |
| Germany Meyer et al., 2008 [27] | 4–6 | dTap DTaP | 20.0 22.2 | 5.6 4.4 | — — | — — | — — | — — | — — | — — | — — | — — | 17.8 17.8 | 0.6 1.1 | 16.1 21.1 | 0.6 2.2 | 10.0 8.9 | 0.0 0.0 | 7.8 4.4 | 0.6 0.0 | — — | — — |
| Thailand Pancharoen et al., 2012 [31] | 4–6 | DTaP − IPV | 10.6 | 0.8 | — | — | — | — | 32.5 | 0.0 | 43.9 | 0.0 | — | — | — | — | — | — | — | — | 24.4 | 0.0 |
| Australia Quinn et al., 2011 [30] | 4–6 | DTaP dTap | 17.4 6.3 | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — | — — |
| Germany Sänger et al., 2007 [23] | 4–8 | dTap − IPV dTap-IPV | 22.1 13.2 | 6.0 1.5 | 20.7 22.8 | 2.6 0.0 | — — | — — | — — | — — | — — | — — | 18.9 17.6 | 2.9 0.0 | 17.5 16.2 | 0.6 0.0 | — — | — — | — — | — — | — — | — — |
| China Zhu et al., 2010 Study A [29] | 6–8 | dTap | 7.0 | — | — | — | 3.0 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| China Zhu et al., 2010 Study B [29] | 6–8 | dTap DT | 17.0 13.5 | — — | — — | — — | 4.0 3.0 | — — | — — | — — | — — | — — | — — | — — | — — | — — | 3.0 4.0 | — — | — — | — — | 3.0 4.5 | — — |
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Interfering with normal activities ∧ ∧Not eating at all
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